摘要
目的旨在探讨慢性心力衰竭患者血清可溶性肿瘤坏死因子受体-I(sTNFR-Ⅰ)、肿瘤坏死因子-α(TNF-α)含量及其临床意义。方法慢性心衰组包括62例慢性心力衰竭患者,按心功能分级(NYHA)又分为3个组:Ⅱ级组20例,Ⅲ级组20例,Ⅳ级组22例,另设15例健康人作对照。血清sTN-FR-Ⅰ、TNF-α含量测定采用酶联免疫吸附法(ELISA)。结果结果显示慢性心力衰竭患者血清sTNFR-Ⅰ、TNF-α含量显著高于健康对照组,慢性心力衰竭患者心功能分级组间血清、sTNFR-Ⅰ、TNF-α含量也有显著差异,心功能Ⅳ级组显著高于心功能Ⅱ级组、Ⅲ级组。结论慢性心力衰竭患者血清sTNFR-Ⅰ、TNF-α含量的变化参与慢性心力衰竭致病机制,它们之间可能还有相互作用及影响,共同参与慢性心力衰竭的发病机制。
Objective To investigate concentrations of serum soluble tumor necrosis factor receptor-I（sTNFR-Ⅰ）,serum tumor necrosis factor（TNF-α）and clinical significance in the patients with chronic heart failure（CHF）.Methods CHF group included 62 patients,sixty-two patients were devided into three groups according to cardiac function（NYHA classification）,class Ⅱ group included 20 patients,class Ⅲ group included 20 patients,class Ⅳ group included 22 patients.Healthy control group included 15 healthy volunteers.Serum concentrations of sTNFR-Ⅰ and TNF-α were measured by enzyme-liked immune-absorbent assay（ELISA）.Results The results were shown that serum concentrations of sTNFR-Ⅰ and TNF-α in the patients with CHF were significantly higher than these in healthy control group,serum levels of sTNFR-Ⅰ and TNF-α in three groups according to cardiac function were also significant difference.Conclusion Changes of serum concentrations of sTNFR-Ⅰ and TNF-αin the patients with CHF would play a role in the pathogenic mechanism of chronic heart failure,they maybe interact and influence each other in the pathogenic mechanism of chronic heart failure.
出处
《中国实用医药》
2011年第12期3-4,共2页
China Practical Medicine
