摘要
目的：了解砂生槐对西藏特殊存在的新型乙肝病毒C／D重组亚型的疗效。方法：①从西藏各地收集砂生槐果子，制成胶囊；②筛选乙型肝炎感染者，服药观察砂生槐治疗疗效；③利用化学发光法及实时定量PCR检测，比较服药前后血液中HBsAg、HBeAg和乙肝病毒DNA的滴度变化。结果：利用西藏当地产砂生槐治疗当地特殊存在的乙肝病毒，发现砂生槐可明显降低HBsAg和HBeAg的滴度。服药前、后HBsAg滴度和HBeAg滴度P值〈0．01，有显著差异，但服药前、后乙肝DNA滴度P值〉0．05，没有差异。结论：西藏当地的砂生槐对西藏特有的乙型肝炎病毒有较好的疗效，应加以深入研究。
Objective To understand the curative effecto-f sophora moorcroftiana on the newly discovered C/D recombinant subtype of HBV, which specially exists in Tibet. Method 1. collecting fruits of sophora moorcroftiana from various places of Tibet and make them into capsules; 2. i- dentify patients with hepatitis B and offering them sophora moorcroftiana capsules to see the curative effect; 3. use chemiluminescence and real--time quantitative PCR detection technology to compare the changes in HBsAg, HBeAg and DNA titers of HBV before and after taken the capsules. Results the sophora moorcroftiana from Tibet can significantly decrease HBsAg and HBeAg titers. The changes of HBsAg and HBeAg titers before and afer taken the capsules are significant （P〈0.01）. However, there are no changes in DNA titers of HBV before and after taken the capsules （P〉0. 05）. Conclusion capsules made out of sophora moorcroftiana growing in Tibet are effective to the special type of HB in Tibet. Thus, futher study is necessary.
基金
本文为西藏自治区科技厅2009年资助项目（项目编号KJTGX1-10-8）
关键词
乙肝病毒
C/D型
砂生槐
hepatitis B
C/D type
sophora moorcroftiana
