摘要
HCN即超级化激活的环核苷酸门控阳离子通道,其激活后产生的If/Ih离子流是窦房结起搏细胞动作电位正常形成的分子基础。随着对窦房结细胞起搏机制和HCN基因家族研究的不断深入,人们对HCN亚型HCN4的结构、分布、特性已有了较深入的了解。近年来有较多研究表明,人窦房结起搏基因HCN4突变与病态窦房结综合征密切相关。现就窦房结细胞起搏基因HCN4的特性及其与窦房结功能之间的关系作进一步研究和探讨。
Hyperpolarization-activated cyclic nucleotide-gated channel,also called HCN,is activated to release If/Ih currents that underlie the molecular mechanisms of action potential in sinoatrial node（SAN） pace-making cells.The further investigations into the pace-making of SAN and HCN gene family allows the understanding of the structure,distribution,and property of HCN subtype 4（HCN4）.Recent studies show that human SAN pace-making gene HCN4 mutations are closely associated with sick sinus syndrome.This article mainly reviews the features of SAN pace-making gene HCN4 in relation to SAN function.
出处
《医学综述》
2011年第10期1441-1444,共4页
Medical Recapitulate
基金
国家自然科学基金(30873332)
