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功能失调性子宫出血的相关分子机制的研究进展 被引量:17

Research Advancement in Molecular Mechanisms of Dysfunctional Uterine Bleeding
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摘要 功能失调性子宫出血(DUB)是妇科内分泌疾病,临床表现为非器质性病变引起的异常子宫出血,严重危害妇女健康,近年来其发病率有逐年上升的趋势。其发病机制不明,可能与调节生殖的神经内分泌机制失常所致的子宫内膜微环境异常有关。现对子宫内膜的血管功能、性激素及其受体,细胞凋亡及基质金属蛋白酶在DUB中的研究进展予以综述。 Dysfunctional uterine bleeding(DUB) is a gynecological endocrine disease,which clinically manifests mainly as non-organic abnormal uterine bleeding.DUB compromises women′s health and with an annually increasing incidence.The etiology of DUB remains unknown,possibly associated with the abnormal uterine microenvironment disorders caused by the neuroendocrine malfunction.This article reviews endometrial vascular function,sex hormones and receptors,apoptosis,and matrix metalloproteinases in the sense of the pathogenesis of DUB.
出处 《医学综述》 2011年第10期1481-1483,共3页 Medical Recapitulate
关键词 功能失调性子宫出血 血管功能 性激素 细胞凋亡 基质金属蛋白酶 Dysfunctional uterine bleeding Vascular function Sex hormones Apoptosis Matrix metalloproteinases
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  • 1Riddihough G, Pennisi E The evolution of epigenetics [ J ] . Science, 2001, 293 (5532): 1063.
  • 2Samuels - Lev Y, O'Connor DJ, Bergamaschi D et al. ASPP proteins specifically stimulate the apoptotic function of p53 [ J ] . Mol Cell, 2001, 8 (4): 781.
  • 3Liu Z J, Lu X, Zhang Yet al. Downregulated mRNA expression of ASPP and the hypermethylation of the 5'- untranslated region in cancer cell lines retaining wild - type p53 [ J] . FEBS Lett, 2005, 579 (7) : 1587.
  • 4Bergamaschi D, Samuels Y, ONeil NJ et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human [ J ] . Nat Genet, 2003, 33 (2): 162.
  • 5Lossos IS, Natkumam Y, Levy R et al. Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B - cell and follicular center lymphoma: correlation with clinical outcome [ J ] . Leuk Lymphoma, 2002, 43 (12) : 2309.
  • 6Zhu Z, Ramos J, Kampa K et al. Control of ASPP2/ (53BP2L) protein levels by proteasomal degradation modulates p53 apoptotie function [J] .JBiolChem, 2005, 280 (41): 34473.
  • 7Bergamaschi D, Sanmels Y, Zhong Set al. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation [J] . Oneogene, 2005, 24 (23): 3836.
  • 8Tidow H, Andreeva A, Rutherford T J et al. Solution structure of ASPP2 N - terminal domain ( N - ASPP2 ) reveals a ubiquitin - like fold [ J] . J Mol Biol, 2007, 371 (4) : 948.
  • 9Bravo R, Frank R, Blundell PA et al. Cyclin/PCNA is the auxiliary protein of DNA polymerase - delta [ J ] . Nature, 1987, 326 (6112) : 515.
  • 10[3]Bozdogan O,Atasoy P,Erekul S,et al.Apoptosis-related proteins and steroid hormone receptors in normal,hyperpiastic,and neopiastic endometrium.Int J Gynecol Pathol,2002,21:375-382.

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