摘要
目的观察粒细胞-巨噬细胞集落刺激因子(GM-CSF)治疗烧伤残余创面(RBW)的效果。方法选取2006年8月至2010年8月在武警8650部队医院治疗的深Ⅱ度烧伤患者120例(RBW 196处),随机分为两组,试验组采用GM-CSF凝胶换药,对照组采用纳米银离子敷料换药治疗,观察用药后的第7、14、21天,两组患者的RBW愈合时间、愈合率及疗效,并对创面进行细菌培养,观察创面感染情况。结果用药后,试验组患者的RBW愈合时间明显低于对照组。用药后第7、14、21天,试验组的创面愈合率分别为39.2%、58.8%、88.2%,对照组的创面愈合率分别为21.3%、47.8%、78.9%,两组比较差异有统计学意义(P<0.05)。两组患者的疗效和创面细菌清除率比较差异均有统计学意义(P<0.05)。两组患者均未产生明显的不良反应。结论 GM-CSF能有效促进RBW的愈合,对治疗RBW具有较好的临床应用价值。
Objective To observe the effect of granulocyte-macrophage colony stimulating factor（GM-CSF） as a treatment for residual burn wounds（RBW）.Methods From August 2006 to August 2010 in 8650 People′s Armed Police Hospital,120 patients of deep burn degree Ⅱ（RBW,n=196） were randomly divided into two groups,GM-CSF cream dressing adopted in the experimental group,nano silver treatment adopted in the control group,observe the healing time,the healing rate and efficacy of the two groups at 7,14,21 days after treatment,culture bacteria on wound to observe the infection.Results After treatment,the healing time of the experimental group was significantly lower than that of the control group.After treatment 7,14,21 days,the average wound healing rate of the experimental group was 39.2%,58.8%,88.2%,while the number of the control group was 21.3%,47.8%,78.9% respectively,a statistically significant difference（P〈0.05）.Theraputic effect and wound bacterial clearance rate of the two groups were both significantly different（P〈0.05）.No significant adverse reactions were observed in the two groups.Conclusion GM-CSF can promote the healing of RWB effectively,presenting a good clinical value.
出处
《医学综述》
2011年第10期1554-1556,共3页
Medical Recapitulate
