摘要
目的 探讨患者年龄,周期数和注入宫腔内前向运动精子总数(NMSI)对宫腔内人工受精(IUI)临床妊娠率的影响.方法 339对夫妇的620个IUI周期,按年龄分为:≤35、35~40、≥40岁组;按周期数分为:第1个、第2个、第3及〉第3个周期;按处理后NMSI分为:〈2、2~5、5~10、10~20及〉20×106组,分别比较各组间的临床妊娠率差别,分析各因素对IUI临床妊娠结局的影响.结果 年龄≤35、35~40及≥40岁组临床妊娠率分别为14.52、17.85及0.00%;第1、第2、第3及〉3个周期临床妊娠率分别为13.86%、18.82%、12.64%及0.00%;NMSI〈2、2~5、5~10、10~20及〉20×106 组临床妊娠率分别为3.13%、18.18%、13.21%、14.83%及16.00%.结论 年龄>40岁,处理后前向运动精子总数低于2×106,以及3~4次IUI尝试仍未成功的患者,不适合继续尝试IUI治疗.
Objective: To explore the effects of female patients' age, number of intrauterine artificial insemination (IUI) cycle and number of motile spermatozoa inseminated (NMSI) on the clinical pregnancy outcomes of IUI treatment. Methods: A total of 620 IUI cycles of 339 couples accomplished in this Center were retrospectively studied. The cycles were grouped according to patients' age (≤35, 35-40 and ≥40 years), number of IUI cycle (the first, the second, the third cycle and more than 3 cycles) and NMSI (-(2, 2-5, 5-10, 10-20 and 〉20 × 10^8) , respectively. The pregnancy rates between groups were compared. Results: The pregnancy rates of the patients aged ≤35, 35-40 and ≥40 years were 14.52%, 17.85% and 0.00%, respectively. The pregnancy rates in the groups of the first cycle, the second cycle, the third cycle and more than 3 cycles were 13.86%, 18.82%, 12.64% and 0.00%, respectively. The pregnancy rates in the groups with NMSI 〈2, 2-5, 5-10, 10-20 and 〉20×10^6 were 3. 13%, 18. 18%, 13.21%, 14.83% and 16.00%, respectively. Conclusions: The patients over 40 years of age, or with 〈2 × 10^6 total motile spermatozoa counts for insemination, or with 3 or more failed IUI cycles, were not suitable for IUI treatment.
出处
《生殖医学杂志》
CAS
2011年第2期116-118,共3页
Journal of Reproductive Medicine