摘要
目的 探讨小于胎龄儿（small for gestational age,SGA）出生后生长追赶状态与血清胰岛素水平的关系.方法 青春前期30例有生长追赶SGA（catch-up growth SGA,CUG-SGA组）、37例无生长追赶SGA（NCUG-SGA组）和42例适于胎龄儿（appropriate for gestational age,AGA组）,测定空腹血糖、空腹胰岛素（FINS）和血清胰岛素样生长因子I（IGF-I）.结果 （1）与NCUG-SGA和AGA组比较,CUG-SGA组FINS和稳态模型评估的胰岛素抵抗指数（HOMA-IR）显著为高（P〈0.01或P〈0.05）,而NCUG-SGA组与AGA组则无显著性差异（P〉0.05）.CUG-SGA组血清IGF-I水平较NCUG-SGA组显著为高[（212.61±17.81对137.40±14.66）ng/ml,P=0.001],但与AGA组无显著性差异（P=0.095）.（2）SGA组HOMA-IR与年龄、身高标准差分值增值（AHtSDS）和体重指数分别正相关;≤6岁SGA组FINS与△HtSDS呈正相关,〉6岁组FINS与体重标准差分值增值呈正相关.结论 生后早期胰岛素可能以生长因子角色参与了SGA儿的生长追赶;胰岛素抵抗程度与生长追赶程度相随.
Objective To evaluate the association between two different linear growth patterns with the levels of serum insulin in children bem small for gestational age（SGA）.Methods Serum fasting glucose,fasting insulin,and insulin-like growth factor-I（IGF-I）concentrations were determined in 30 catch-up growth（CUG）children bern SGA [CUG-SGA,16 females,14males,（6.62±0.66）year],37 non-catch-up growth（NCUG）children born SGA[NCUG-SGA,15 females,22 males,（5.97±0.56）year],and42 appropriate for gestational age（AGA）children with normal height[AGA,16females,26males,（7.05±0.39）year].Results （1） Basal fasting insulin and homeostasis model assessment for insulin resistance（HOMA-IR）were significantly higher in CUG-SGA group than in NCUG-SGA and AGA group（P〈0.01 or P〈0.05）.But there was no difference in fasting insulin between NCUG-SGA group and AGA group.IGF-I levels in CUG-SGA were significantly higher than in NCUG-SGA group[（212.61±17.81 vs 137.40±14.66）ng/ml,P=0.001],but showed no difference from AGA group（P=0.095）.（2）In the SGA group,HOMA-IR showed positive correlation with age,△height SDS,and current body mass index.Fasting insulin showed positive correlation with △height SDS（r=0.500,P=0.002）in≤6 year group as well as with △weight SDS（r=0.496,P=0.030）in〉6 year group.Conclusions Insulin as a growth factor may participate in postnatal catch-up growth accompanied with increased insulin resistance in SGA children.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2011年第4期296-300,共5页
Chinese Journal of Endocrinology and Metabolism
基金
广东省自然科学基金（9151008901000079）
关键词
生长追赶
胰岛素抵抗
小于胎龄儿
Catch-up growth
Insulin resistance
Small for gestational age
