摘要
脂质体具有靶向传递药物进入肿瘤部位的优势,被广泛用于肿瘤的临床治疗,但是靶向传递并不能保证药物在肿瘤部位被生物利用。为了解决此问题,热敏靶向脂质体(TTL)已经成为目前的研究热点。TTL既能提高药物在肿瘤部位的浓度,又能在加热条件下触发释放所载药物,从而显著改善所载药物的抗肿瘤效果。本文主要综述了近年来该领域的研究进展。
Liposomes which offer the advantage of the enhanced drug accumulation at tumor sites are currently applied extensively in the clinical treatment of tumor. However, accumulation of the liposomes in the tumor area cannot guarantee the drug bioavailability. To resolve the question, thermosensitive targeting liposomes （TTL） have been the hotspot of current studies. TTL can enhance drug accumulation at tumor sites and be triggered to release their contents upon hyperthermia. By applying these two strategies, antitumor efficacy of encapsulated drug can be significantly improved. The present paper reviews the development of TTL in recent years.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第5期502-506,共5页
Acta Pharmaceutica Sinica
基金
江苏省青蓝工程资助项目
关键词
脂质体
靶向给药
抗肿瘤药物
触发释放
liposome
drug targeting
antitumor drug
triggered release
