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表皮生长因子受体拮抗剂治疗头颈部癌的进展 被引量:3

Advances of Epidermal Growth Factor Receptor Inhibitors in Head and Neck Cancer Therapy
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摘要 在我国,头颈部癌(head and neck cancer,HNC)的发病率约为9/10 000,约占全身恶性肿瘤的8.2%。近年来,分子生物学和分子病理学不断发展,新的分子靶向药物涌现,为头颈部癌的治疗提供了更多选择。表皮生长因子受体拈抗剂就是其中之一。
作者 马捷 张志愿
出处 《口腔颌面外科杂志》 CAS 2011年第2期142-146,共5页 Journal of Oral and Maxillofacial Surgery
基金 国家自然科学基金资助项目(30630065)
关键词 表皮生长因子受体(EGFR) 抗EGFR单克隆抗体 小分子EGFR酪氨酸激酶抑制剂 头颈部癌 epidermal growth factor receptor anti-EGFR monoclonal antibody small molecule tyrosine kinase inhibitors head and neck cancer
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同被引文献13

  • 1Liu J, Shao C, Tan ML, et al. Molecular biology of adenoid cystic carcinoma [J]. Head Neck, 2012, 34(11): 1665-1677.
  • 2Liu AM, Wong KF, Jiang X, et al. Regulators of mammalian Hippo pathway in cancer[J]. Biochim Biophys Acta, 2012, 1826(2):357-364.
  • 3Fan R, Kim NG, Gumbiner BM. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-l[J]. Proc Natl Acad Sci U S A, 2013, 110(7):2569-2574.
  • 4Hiemer SE, Varelas X. Stem cell regulation by the Hippo pathway [J]. Biochim Biophys Acta, 2013, 1830(2):2323- 2334.
  • 5Barry ER, Camargo FD. The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development [J]. Curr Opin Cell Biol, 2013, 25(2):247-253.
  • 6Yuan S, Yu SL, Chen HY, et ah Clustered genomic alterations in chromosome 7P dictate outcomes and targeted treatment responses of lung adenolarcinoma with EGFR-activating mutations [J]. J Clin Oncol, 201129(25): 3435-3442.
  • 7Antonieelli A, Cafarotti S, Indini A, et al. EGFR-targeted therapy for non-small cell lung cancer: focus on EGFR oncogenic mutation [J]. Int J Med Sci, 2013, 10(3):320- 330.
  • 8刘红雨,李颖,陈钢,王竞,李永文,王玉丽,韦森,朱大兴,邱小明,王伟强,宋作庆,陈军,周清华.187例非小细胞肺癌中EGFR基因突变和扩增的检测及其临床意义[J].中国肺癌杂志,2009,12(12):1219-1228. 被引量:40
  • 9邱嘉旋,魏军水,朱声荣,曹钟义.Ki-67、EGFR、p53及RARβ在口腔鳞癌化疗前后的变化及临床意义评价[J].口腔医学研究,2011,27(2):127-131. 被引量:15
  • 10林远洪,雷小林,吴永忠,张敬卫.靶向EGFR基因的shRNA对胰腺癌细胞放疗敏感性的增强作用[J].中国老年学杂志,2011,31(5):797-799. 被引量:3

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