摘要
目的：对筛选的黄连、黄柏、姜黄素、紫草素四种中药提取物进行豚鼠皮肤光毒性试验,预测这几种物质在UVA波长范围是否有潜在的皮肤光毒性。方法：动物选择普通级别白化豚鼠30只,光源规格为PHILIPS公司生产TL60W/10R,UVA波长320~400 nm,波长峰值365 nm。UVB〈0.1 J/cm2,按照07年卫生部化妆品规范中的动物皮肤光毒性试验进行。结果：这四种物质在UVA波长范围的动物光毒性试验中均未显示有光毒性。结论：按照化妆品安全性检测,这四种中药提取物可以添加于化妆品中应用。
Objective：The extracts of coptis,phellodendron,curcumin and shikonin were topically used to guinea pig skin for phototoxicity test to investigate on the potential skin phototoxicity.Methods：The 30 animals selected ordinary level in albino guinea pigs,the UVA source was specifications for the PHILIPS company TL60W/10R,wavelength was between 320~400 nm,the peak wavelength was 365 nm.UVA0.1 J/cm2,The test was under the guide with the 2007 Ministry of Public Health in the animal skin cosmetics phototoxicity tests.Results：The skin phototoxicity test in animals by the four substances in the warelength were not showed phototoxicity.Conclusion：The four herbal extracts in accordance with the safety testing of cosmetics can be added to cosmetics production.
出处
《皮肤性病诊疗学杂志》
2011年第2期76-78,82,共4页
Journal of Diagnosis and Therapy on Dermato-venereology
基金
卫生部化妆品标准委员会项目<化妆品光斑贴实验标准变应原制备>
关键词
中药
动物光毒性试验
光毒性
Chinese herbs
Skin Phototoxicity Test
Phototoxicity
