摘要
目的观察华佗麻药加减方对豚鼠局限性湿疹样模型的疗效。方法采用2,4-二硝基氯苯(DNCB)诱导豚鼠局限性湿疹样模型,以丁酸氢化可的松为阳性对照,乳膏基质为阴性对照,评价华佗麻药加减方对模型皮损及组织形态学的作用。结果经治疗2周,华佗麻药加减方组症状评分明显降低,与基质组比较差异有显著性(P<0.05),氢化可的松组与华佗麻药加减方组比较无显著性差异(P>0.05),两组的疗效指数均大于50%。结论华佗麻药加减方对豚鼠慢性湿疹具有较好的治疗作用。
Objective To observe the effect of Modified Huatuo＇s External Application Anesthetic Recipe on guinea pig models of localized eczema.Methods Localized eczema was induced by dinitrochlorobenzene（DNCB） in guinea pigs.With hydrocortisone as the positive control and with pure cream matrix as the negative control,the effect of Modified Huatuo＇s External Application Anesthetic Recipe on skin lesions and morphology of guinea pig models was evaluated.Results After treatment for two weeks,significant differences could be observed in symptom scores between Chinese medicine group and pure cream matrix group（P 0.05）.However,the differences of symptom scores were insignificant between Chinese medicine group and hydrocortisone group（P 0.05）.The efficacy index of Chinese medicine group and hydrocortisone group were over 50 %.Conclusion Modified Huatuo＇s External Application Anesthetic Recipe shows certain effect for the treatment of chronic eczema in guinea pigs.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2011年第3期292-295,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
华佗麻药加减方
慢性湿疹
豚鼠模型
皮损
组织形态
Modified Huatuo＇s External Application Anesthetic Recipe
Chronic eczema
Guinea pig models
Skin lesions
Morphology
