摘要
共刺激分子是T细胞激活的第二信号,有促进T细胞生长、分化和细胞因子产生的正调控分子,也包括诱导和维持T细胞免疫耐受以至凋亡的负调控分子。将从这两方面对共刺激分子在肿瘤免疫,尤其在宫颈癌中的相关研究方面进行综述。
Costimulatory molecules are the second signal for the activation of T cell.These costimulatory molecules not only provide critical positive signals that stimulate T cell growth,promote T cell differentiation and up-regulate cytokine production,but also contribute key negative signals that induce and maintain T cell immune tolerance,even to apoptosis.This article reviews the advances of costimulatory molecules in the tumor immunity,especially in the cervical cancer.
出处
《生命科学》
CSCD
北大核心
2011年第5期449-453,共5页
Chinese Bulletin of Life Sciences
关键词
共刺激分子
肿瘤
免疫
宫颈癌
costimulatory molecules
tumor
immunity
cervical cancer
