摘要
目的观察氯沙坦治疗原发性高血压(EH)时对纤溶活性、内皮素、一氧化氮、降钙素基因相关肽的影响。方法 48例健康体检者作为正常对照组,68例EH患者用氯沙坦治疗8周,观察用药前后血t-PA、PAI活性,ET、NO、CGRP浓度的变化。结果 EH患者t-PA活性、CGRP和NO浓度明显低于正常对照组(P<0.01),而PAI活性、ET浓度明显高于正常对照组(P<0.01),氯沙坦治疗后,血t-PA活性、NO、CGRP浓度均较治疗前显著升高(P<0.01),血PAI活性、ET浓度显著下降(P<0.01)。结论 EH患者纤溶活性和内皮功能异常,氯沙坦可改善EH患者纤溶活性和内皮功能。
Objective To investigate the effects of losartan on fibrinolytic activity,endothlin,nitric oxide and calationin gene related peptide in patients with essential hypertension.Methods Fouty-eight healthy persons were assigned as normal control group,sixty-eight patients with essential hypertension were treated with losartan for 8 weeks,plasma activity of tissuetype plasminogen activator（t-PA）,plasminogen activator inhibitor（PAI） and plasma concentration of endothelin（ET）,nitric oxide（NO） and calatonin gene related peptide（CGRP） were measured before and after treatment.The treatment time was eight weeks.Results Plasma activity of t-PA and plasma concentration of NO,CGRP in ptients with essential hypertension were sinificantly reduced compared with the patients in normal control group（P0.01）, plasma activity of PAI and plasma concentration of ET in patients with essential hypertension were remarkly hihger compared with the patients in normal control group（P0.01）.After treatment,plasma activity of t-Pa and plasma concentration of NO,CGRP were significantly elevated（P0.01）,and plasma activity of PAI and plasma concentration of ET were remarkly decreased（P0.01）.Conclusion The plasma activity of tPA,PAI and plasma concentration of ET,NO,CGRP are abnormal in patients with essential hypertension.Losartan can improve fibrinolytic activity and endothelial function in patients with essential hypertension.
出处
《河南职工医学院学报》
2011年第2期143-145,共3页
Journal of Henan Medical College For Staff and Workers
关键词
氯沙坦
纤溶活性
内皮素
一氧化氮
降钙素基因相关肽
losartan
fibrinolytic activity
endothelin
nitric oxide
calationin gene related peptide
