摘要
目的分析双源CT双能量肺灌注成像（DEPI）技术评价急性肺动脉栓塞（APE）严重程度的可行性。方法经双源CT诊断APE24例,采用Lung PBV软件进行数据处理,得到CT肺血管图像（CTPA）和DEPI,分别计算每位患者的灌注缺损指数、栓塞指数及双室短轴最大径比（RV/LV）,依据患者严重程度分为严重APE组（n=9）和非严重APE组（n=15）,比较两组灌注缺损指数、栓塞指数及RV/LV,并进行Spearman等级相关分析。结果严重APE组的灌注缺损指数、栓塞指数及RV/LV中位数分别为32.5%（15.0%62.5%）、45.0%（27.5%75.0%）和1.16（1.041.45）,而非严重APE组分别为12.5%（0%37.5%）、12.5%（2.5%42.5%）和1.03（0.851.41）,严重APE组的各项指标均高于非严重组,两组间差异有统计学意义（P〈0.05）。相关分析显示,灌注缺损指数与RV/LV及栓塞指数均呈正相关（分别为r=0.635,P〈0.05;r=0.790,P〈0.05）。结论采用双源CT双能量肺灌注成像技术评价APE严重程度具有一定可行性。
Objective To prospectively evaluate the feasibility of dual-source computed tomography（DSCT） dual energy perfusion imaging（DEPI） for assessment of the severity of acute pulmonary embolism（APE）.Methods The data of twenty-four patients who underwent DSCT scan were analyzed by Lung PBV software.Computed tomography pulmonary angiography（CTPA） and DEPI was obtained.Dual energy CT pulmonary perfusion defect index,CT pulmonary angiographic obstruction index,and right ventricular maximal short axis to left ventricular maximal short axis ratio（RV/LV） were separately calculated by DEPI and CTPA.Spearman correlation coefficient was used to assess the correlation of the 3 indexes.The patients were divided into severe APE group（n=9） and non-serious APE group（n=15） according to the severity of APE.The difference of the 3 indexes was compared between severe APE group and non-serious APE group.Results The median of perfusion defect index,obstruction index and RV/LV in severe APE group was respectively 32.5%（15.0%-62.5%）,45.0%（27.5%-75.0%） and 1.16（1.04-1.45）,while in non-serious group it was 12.5%（0%-37.5%）,12.5%（2.5%-42.5%） and 1.03（0.85-1.41） respectively.The 3 indexes were higher in severe APE group than in non-serious APE group with significant statistical differences（P〈0.05）.The perfusion defect index had moderate correlation with RV/LV（r=0.635,P〈0.05）,and better correlation with CTPA obstruction index（r=0.790,P〈0.05）.Conclusion DEPI of the dual-source CT is feasible to assess the severity of acute pulmonary embolism.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2011年第5期526-529,共4页
Medical Journal of Chinese People's Liberation Army
