摘要
目的探讨乳腺癌全乳腺切除术后胸壁电子束照射的疗效。方法回顾分析1999—2007年间全乳腺切除术后进行胸壁6MeV电子束照射及锁骨上下区淋巴结引流区6～8MVX线和12—15MeV电子束混合照射患者280例资料，并与同期胸壁6～8MVX线切线野照射118例进行比较。结果随访率为93．2％，随访满5、10年者分别为140、12例。电子束组和X线组的5、10年胸壁复发率分别为6．8％和5．O％、14．8％和10．1％（X。=1．12，P=0．290），5、10年无瘤生存率分别为60．6％和65．5％、47．6％和57．3％（x2=0．97，P=0．325），5、10年总生存率分别为77．5％和79．6％、48．4％和53．3％（x2=0．37，P=0．545），〉2级皮肤急性不良反应率分别为10．4％和16．9％（x2=3．34，P=0．090），肺纤维化率分别为28．8％和22．1％（X2=1．27，P=0．300）。结论乳腺癌全乳腺切除术后胸壁电子束照射的肿瘤控制率及不良反应与胸壁切线野照射无差别。
Objective To evaluate the efficacy of electron-beam chest-wall irradiation in patients with breast cancer after mastectomy. Methods From June 1999 to December 2007, 280 women with localized breast cancer received postmastectomy radiotherapy using electron beam to chest wall. The efficacy and toxicity of these 280 women was compared with 118 women treated during the same period using tangential field with photon beam. Results The follow-up rate was 93.2%. 140 patients had a minimum followed up time of 5 years and 12 patients had a minimum follow up time of 10 years. The 5-year and 10- year chest wall recurrence rates were 6. 8% and 5.0%, 14. 8% and 10. 1% for patients irradiated with electron and photon （ x2 = 1.12, P = 0. 290 ）. The corresponding 5-year and 10-year disease-free survival rates were 60. 6% and 65.5% ,47.6% and 57.3% （ X2 = 0. 97 ,P = 0. 325）. The 5-year and 10-year overall survival rates were 77. 5% and 79. 6% , 48.4% and 53.3% （ X2 = 0. 37, P = 0. 545 ）. Grade 1I or more acute skin toxicity occurred in 10. 4% and 16.9% of patients irradiated with electron and photon （X2 = 3.34,P =0. 090）. Pulmonary fibrosis developed in 28.8% and 22. 1% of patients irradiated with electron and photon （ X2 = 1.27, P = 0. 300）. Conclusion Electron-beam chest-wall irradiation is as effective as photon-beam irradiation in breast cancer after mastectomy.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2011年第3期211-214,共4页
Chinese Journal of Radiation Oncology
关键词
乳腺肿瘤/放射疗法
放射疗法
电子束
预后
Breast neoplasms/radiotherapy
Radiotherapy,electron-beam
Prognosis
