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脂肪酸合成酶、Ki-67在骨肉瘤中的表达及其与转移的相关性 被引量:5

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摘要 目的:研究FASN和Ki-67蛋白在骨肉瘤组织中表达程度与骨肉瘤转移的关系。方法:应用免疫组织化学SP方法检测60例骨肉瘤组织中FASN和Ki-67蛋白表达情况,21例骨软骨瘤组织作为对照。结果:FASN在骨肉瘤组和骨软骨瘤组阳性表达分别60.0%(36/60)、28.6%(6/21),差异有显著性(P<0.05)。骨肉瘤转移组FASN阳性表达率为85.7%,明显高于无转移组(52.2%)。骨肉瘤组Ki-67增殖指数为(35.12±15.16)%,骨软骨瘤组为(2.05±0.86)%,差异有显著性(t=2.74,P=0.007)。骨肉瘤转移组Ki-67增殖指数为(48.32±20.12)%,无转移组为(21.18±10.18)%,差异有显著性(t=2.08,P=0.04)。结论:FASN和Ki-67蛋白在骨肉瘤组织中呈高表达,与骨肉瘤的发生及远处转移正相关。
出处 《实用医学杂志》 CAS 北大核心 2011年第10期1803-1805,共3页 The Journal of Practical Medicine
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