摘要
目的:探讨鳖甲煎丸对糖尿病合并动脉粥样硬化病变的作用机理。方法:清洁级SD大鼠90只按随机数字表法随机分为空白组、模型组、通心络组、鳖甲煎丸低剂量组与鳖甲煎丸高剂量组。灌胃56 d后取材,放免法检测血清C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)含量,胸主动脉免疫组化检测基质金属蛋白酶-9(MMP-9)表达水平。结果:鳖甲煎丸低剂量组与鳖甲煎丸高剂量组大鼠的血清CRP、TNF-α水平较模型组降低(P<0.05),免疫组化MMP-9表达较模型组降低(P<0.05)。结论:鳖甲煎丸具有抗糖尿病合并动脉粥样硬化病变,稳定斑块的作用,其机制可能与降低炎症因子水平有关。
To study the mechanisms of Biejiajian pill in SD rats with Diabetic Atherosclerosis. Methods：The modeling real, SD rats were divided randomly into normal control group, model group, Tongxinluo control group, low dose of Biejiajian pill group, and high dose of Biejiajian pill group. After 8 weeks, drawing blood and taking thoracic aorta and examination：①CRP,TNF-α;②the ex pression of MMP-9 in thoracic aorta by immunohistochemistry. Results ： The level of CRP and TNF-α decreased （P 〈 0.05 ） and th~ expression of MMP-9 decreased（P 〈 0.05 ） significantly compared with model group in Biejiajian pill low and high dosage groups. Conclusion ： Biejiajian pill has effect of anti-diabetic atherosclerosis in SD rats probably related with the decrease of inflammatory fae tor.
出处
《中医学报》
CAS
2011年第5期589-591,共3页
Acta Chinese Medicine
基金
河南省科技攻关计划项目(编号:092102310345)
关键词
鳖甲煎丸
糖尿病
炎症因子
biejiajian pill
diabetes mellitus
inflammatory factor
