摘要
目的观察脑局部亚低温治疗对急性脑梗死患者血清中神经元特异性烯醇化酶(NSE)、S-100蛋白浓度的影响和临床疗效,探讨其对脑缺血的保护机制。方法随机将66例急性脑梗死患者分为治疗组和对照组各33例,治疗组在药物治疗脑梗死的同时加用局部亚低温治疗技术,在发病后1、3、7、14 d进行NSE、S-100蛋白含量的测定,在治疗前和治疗后7、14、30 d根据《美国国立卫生研究所脑卒中量表》(NIHSS)进行神经功能缺损评分。结果与对照组比较,治疗组治疗14、30 d后神经功能缺损评分降低(P<0.01),发病后3、7、14 d血清NSE含量明显降低(P<0.01),治疗7、14 d S-100蛋白含量降低(P<0.05)。结论局部亚低温治疗技术对神经细胞有较好的保护作用,可改善急性脑梗死患者神经功能缺损及预后。
Objective To observe clinical efficacy of local mild hypothermia therapy and its influence on serum contents of neuron-specific enolase（NSE） and S-100 protein in patients with acute cerebral infarction.Methods 66 patients were randomly divided into the treatment group（33 cases） and the control group（33 cases）.Drugs were used in both groups,and local mild hypothermia therapy only was applied to the treatment group.Nerve function deficiency was scored by the National Institutes of Health Stroke Scale（NIHSS） before and after 7 d,14 d and 30 d of treatment.Serum contents of NSE and S-100protein were observed 1 d,3 d,7 d and 14 d after stroke.Results Nerve function deficiency scores after 14 d and 30 d of treatment were lower in the treatment group than those in the control group（P0.01）.Serum contents of NSE 3 d,7 d and 14 d after stroke（P0.01） and S-100 protein 7 d and 14 d（P0.05） after stroke were also significantly lower.Conclusion Local mild hypothermia therapy can protect neural cells and improve the nerve function in patients with acute cerebral infarction.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第4期103-104,109,共3页
Journal of Shandong University:Health Sciences
基金
山东省科技攻关计划资助项目(2006GG2202036)
