摘要
目的:观察应用促红细胞生成素(erythropoietin,EPO)治疗新生儿缺氧缺血性脑病(hypoxia ischemic encephalopa-thy,HIE)的疗效。方法:将80例HIE患儿随机分为治疗组和对照组,每组各40例,两组患儿均采用常规治疗方法,治疗组在此基础上于生后第3天应用促红细胞生成素每次300 IU/kg,首次皮下注射,以后静脉注射,每周3次,连续2周。在生后14 d进行新生儿神经行为测定(NBNA),生后10个月采用Gesell量表及Bayley婴幼儿发展量表进行评定。结果:两组患儿在生后14 d进行NBNA测定,治疗组行为能力、被动肌张力、主动肌张力、原始反射及一般评估五个部分分值均高于对照组,两组比较,差异有统计学意义(P<0.05或P<0.01);两组患儿在生后10个月进行Gesell量表评定,治疗组大运动能区、精细运动能区、语言能区、个人社交能区及社会适应能区五大能区DQ分值均高于对照组,两组比较,差异有统计学意义(P<0.05或P<0.01);两组患儿在生后10个月进行Bayley婴幼儿发展量表评定,治疗组智能发育指数(MDI)和运动发育指数(PDI)均高于对照组,两组比较,差异有统计学意义(P<0.05或P<0.01)。结论:促红细胞生成素治疗新生儿缺氧缺血性脑病疗效肯定,临床可推广应用。
Objective： To observe the efficacy of erythropoietin oxygen（EPO） in the treatment of neonatal hypoxia ischemic encephalopathy（HIE）.Methods： 80 cases of newborn infants with hypoxia ischemic encephalopathy were randomly divided into treatment group（40 cases） and control group（40 cases）,they were given the conventional treatment,and based on these,the treatment group were used erythropoietin（300 IU/kg） after born 3 days,first subcutaneously after intravenous,every week three times,consecutive 2 weeks.In life 14 days after a new neurobehavioral measurement（NBNA）,born after 10 months Gesell scale,and by Bayley infant development scale was evaluated.Results： After 14 days for NBNA determination in the two groups,behavior ability,passive,hypotonia,initiative,hypotonia,primitive reflex and general assessment of five parts of the treatment group were higher than those of the control group,and score two groups of comparisons difference was statistically significant（P0.05 or P0.01）.Born after 10 months,Gesell scale evaluation was used in the two groups,the kinetic energy area,meticulous motion can area,language can area,the district DQ of personal social can area and social adaptation can area five can score of the treatment group were higher than those of the control group,there were significant differences in the two groups（P0.05 or P0.01）.Comparison in the two groups born after 10 months,Bayley infant development scale assess,the treatment group intelligent development index（MDI） and sports development index（the PDI） were higher than those of the control group,there were significant differences in the two groups（P0.05 or P0.01）.Conclusion： Erythropoietin in the treatment of neonatal hypoxia ischemic encephalopathy affirmation,the efficacy is definite,and can be popularized.
出处
《中国医药导报》
CAS
2011年第16期56-58,共3页
China Medical Herald
