摘要
目的:探讨不同严重度慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清MMP-9、TIMP-1的浓度变化及相关性。方法:用酶联免疫吸附法(ELISA)测定53例不同病情分度的COPD患者(轻度11例、中度16例、重度14例、极重度12例)血清MMP-9、TIMP-1的浓度(ng/ml)。结果:与轻度(52.46±10.59;161.63±7.26)COPD患者相比,中度(111.73±25.40;201.73±19.27)、重度(188.41±20.72;257.05±13.97)、极重度(236.31±10.93;313.07±15.97)患者血清MMP-9、TIMP-1浓度显著升高。与中度COPD患者相比,重度、极重度患者血清MMP-9、TIMP-1浓度显著升高;与重度COPD患者相比,极重度患者血清MMP-9、TIMP-1浓度显著升高,P均<0.05;不同COPD病情严重度与MMP-9、TIMP-1、MMP-9/TIMP-1均呈正相关,相关系数分别为0.791,0.782,0.766,P<0.01。结论:随着COPD患者病情严重程度的加重,血清MMP-9、TIMP-1的浓度及MMP-9/MMP-1比率升高,并且与气流阻塞(用FEV1/FVC%及FEV1%预计值表示)成负相关,可以作为评价患者病情严重程度的指标,也可初步预测治疗效果。
Objective：To estimate the serum concentration of matrix metalloproteinase-9（MMP-9）,tissue inhibitors of matrix metalloproteinase（TIMP-1） in the patients with chronic obstructive pulmonary disease（COPD） and to evaluate the correlation between MMP-9 and TIMP-1 with the disease severity in COPD.Methods：Fifity-three COPD patients were enrolled（mild 11,moderate 16,severe 14,extreme severe 12）.In four groups the spirometry was performed and the serum concentrations were measured using enzyme-linked immunosorbent assay（ELISA）.Results：Moderate,severe and extreme severe COPD patients had increased serum MMP-9 and TIMP-1 levels compared with mild COPD patients.Furthermore,severe and extreme severe COPD patients had increased serum MMP-9 and TIMP-1 levels compared with moderate COPD patients.The extreme severe COPD patients had significantly increased serum MMP-9 and TIMP-1 levels than severe COPD（all P0.05）.The different disease severities of COPD all were positively correlated with serum MMP-9 and TIMP-1 levels and MMP-9/ TIMP-1.The related coefficients were 0.791,0.782 and 0.766 respectively（P0.01）.Conclusion：With the aggravation of severities in COPD,serum MMP-9 and TIMP-1 levels and MMP-9/TIMP-1 ratio all are increased and negatively correlated with airflow obstruction（FEV1/FVC% and FEV% predicted value）,which might be used as the indexes for evaluating the disease severity and preliminarily predicting the curative effects.
出处
《现代医药卫生》
2011年第9期1289-1290,共2页
Journal of Modern Medicine & Health
