摘要
目的:观察复方甘草酸苷联合还原型谷胱甘肽治疗抗结核药所致肝损害的临床疗效。方法:将69例抗结核药引起的药物性肝炎患者随机分成观察组37例和对照组32例,观察组给予复方甘草酸苷联合还原型谷胱甘肽治疗4周,对照组给予还原型谷胱甘肽治疗4周,观察两组患者治疗前后肝功能指标情况、治疗总有效率及药物不良作用。结果:观察组患者的肝功能指标改善情况优于对照组(P<0.05,P<0.01),观察组与对照组总有效率分别为91.9%和71.9%(P<0.05),未见药物不良反应。结论:复方甘草酸苷联合还原型谷胱甘肽对于抗结核药引起的药物性肝炎具有较好的降酶保肝作用。
Objective：To investigate the treatment efficacy of liver damage caused by antituberculosis drugs with compound glycyrrhizin and reduced glutathione.Methods：69 patients of anti-TB drug-induced hepatitis were randomly divided into control group（32 cases） and observation group（37 cases）.In the observation group,compound glycyrrhizin and reduced glutathione were given for 4 weeks,while in the control group,reduced glutathione was given for 4 weeks.Liver function before and after treatment,treatment efficacy and adverse drug reactions in the two groups were observed.Results：The improvement of liver function in the observation group was better than that in the control group（P0.05,P0.01）.The effective rates of the observation group and the control group were 91.9% and 71.9% respectively（P0.05）.No adverse drug reactions were observed in the two groups.Conclusion：Treatment with compound glycyrrhizin and reduced glutathione for anti-TB drug-induced hepatitis has good effects on reducing enzymes and protecting liver.
出处
《现代医药卫生》
2011年第9期1308-1309,共2页
Journal of Modern Medicine & Health
