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亚综合征抑郁B细胞淋巴瘤白血病-2基因表达研究 被引量：5

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摘要 目的探讨B细胞淋巴瘤白血病-2(Bcl-2)基因与亚综合征抑郁的关系。方法应用TaqMan探针及荧光实时定量逆转录-聚合酶链反应方法,检测亚综合征抑郁组(64例)与正常对照组(64例)外周血白细胞Bcl-2基因的mRNA表达水平的差异;应用汉密尔顿抑郁量表17项(Hamilton Depression Rating Scale 17,HAMD17)评定患者的抑郁症状。结果亚综合征抑郁组Bcl-2基因mRNA相对表达水平低于正常对照组[(0.34±0.11)vs(0.41±0.13),P<0.01],亚综合征抑郁组Bcl-2表达水平与HAMD17评分的相关不具有统计学意义(r=-0.22,P>0.05)。结论 Bcl-2基因低表达可能与亚综合征抑郁的病理生理机制有关。
作者 李则挚 张晨 洪武 苑成梅 易正辉 汪作为 吴志国 黄佳 禹顺英 方贻儒
机构地区 上海交通大学医学院附属精神卫生中心心境障碍科 上海交通大学医学院附属精神卫生中心遗传研究室
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2011年第5期307-309,共3页 Chinese Journal of Nervous and Mental Diseases
基金 国家高科技研究发展计划(编号:2006AA02Z430) "十五"国家科技攻关计划(编号:2004BA720A21-02) 国家自然科学基金(编号:30971047 81000581)
关键词 亚综合征抑郁 B细胞淋巴瘤白血病-2 基因表达
分类号 R733.1 [医药卫生—肿瘤]
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参考文献14

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共引文献10

同被引文献69

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引证文献5

二级引证文献21

中国神经精神疾病杂志
2011年 第5期

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