摘要
目的通过对三氯生和硫酸庆大霉素两种抗菌活性骨水泥的进行压缩强度、弯曲强度和弹性模量测试分析,比较两种抗菌活性骨水泥的生物力学性能。方法实验分为三氯生组、硫酸庆大霉素组及空白对照组,将三氯生和硫酸庆大霉素分别以0.5∶40、1.0∶40、1.5∶40、2.0∶40的剂量比例与骨水泥混合,制成符合实验标准的模件,每组6根,然后放在生物力学机上进行测试。结果压缩强度检测表明,将2.0 g三氯生混入40 g骨水泥中,压缩强度为(72.4±4.14)Mpa,大于ISO 5833标准中规定的抗压强度70 Mpa,和对照组(无抗生素的骨水泥)相似。而根据ISO 5833对四点弯曲测试提出的标准,三氯生骨水泥产品弯曲模量为(1854±57)Mpa>1800 Mpa,弯曲强度(为51.8±2.07)Mpa>50 Mpa。结论生物力学实验表明,本实验剂量下的三氯生骨水泥的生物力学效果优于硫酸庆大霉素骨水泥,与无抗生素的骨水泥相似且压缩强度、弯曲模量和弯曲强度均达标。
Objective To evaluate the bio-mechanical efficacy of two kinds of bone cement through experimental analysis of compressive strength, flexural strength and elastic modulus. Methods The tests were divided into three groups： control group （n=6 each）, triclosan group（n=6 each）and gentamicin sulfate group（n=6 each）.Triclosan and gentamicin sulfate of the different doses （0.5 g, 1.0 g, 1.5 g, 2.0 g） mixed with bone cement respectively. The samples were in accord with the standards completely,and the bio-mechanics of the bone cement were investigated. Results Comparison of compressive strength showed that the compressive strength was as high as 70 Mpa. The physical mechanical performance of the bone cement was similar to that of control group bone cement, when weight ratio of triclosan bone cement was 2.0：40,compression strength（72.4±4.14）Mpa. According to ＂surgical implants -acrylic resin cement＂ standard, elastic modulus（1854±57）Mpa〉l 800 Mpa,flexural strength（51.8±2.07）Mpa〉50 Mpa. Conclusion Our experiment in vivo shows that biomechanical efficacy of bone cement loading with triclosan is better than bone cement loading with Gentamicin. Compressive strength, flexural strength and elastic modulus of bone cement loading with triclosan meet the ISO 5833 standards.
出处
《中国骨与关节损伤杂志》
2011年第5期398-400,共3页
Chinese Journal of Bone and Joint Injury
基金
国家自然科学基金资助项目(30471755)
关键词
三氯生
硫酸庆大霉素
抗菌活性骨水泥
生物力学
Triclosan
Gentamicin sulfate
Bone cement of anti-bacterial activity
Biomechanic
