期刊文献+

原发中枢神经系统淋巴瘤临床特点与疗效:40例分析 被引量:8

A Prognosis Analysis of 40 Cases of Primary Central Nervous System Lymphoma
下载PDF
导出
摘要 背景与目的:原发中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)近年来在免疫功能正常的人群中发病率有所上升。本研究的目的是探讨PCNSL的临床特征、治疗及预后。方法:回顾性分析经病理证实的40例PCNSL的临床资料。结果:40例患者中24例(60.0%)主要表现为颅内高压;21例(52.5%)单发病灶;28例(70.0%)为弥漫大B细胞淋巴瘤。12例(30.0%)手术全切肿瘤,中位KPS评分70;14例(35.0%)接受HD-MTX为主的化疗加全脑放疗;19例(47.5%)接受鞘内化疗。40例患者Kaplan-Meier分析总中位生存时间为26个月,2年生存率65.2%;HD-MTX联合全脑放疗组患者完全缓解率73.3%,中位生存时间38.5个月,2年生存率80.6%。结论:PCNSL患者临床表现主要为颅内压增高,单发病灶多见,B细胞亚型多见,HD-MTX联合适当剂量的全脑放射治疗可延长生存期,年龄、术后KPS评分影响预后。 BACKGROUND OBJECTIVE: In recent years,the incidence of primary central nervous system lymphoma(PCNSL) increases in the immunocompetent patients.The purpose of this study is to explore the clinical characteristics,treatment and the prognosis of PCNSL.METHODS: Forty pathology-confirmed PCNSL cases were analyzed retrospectively.RESULTS: Of the 40 patients,24(60.0%) had increased cranial pressure as the major symptom.Twenty-one(52.5%) had single tumor location.Twenty-eight(70.0%) had diffuse large B-cell lymphoma.Twelve(30.0%)cases had total resection.The median Karnofsky performance score(KPS) was 70.Fourteen(35.0%) received HD-MTX-based chemotherapy in combination with whole brain radiotherapy(WBRT).Nineteen(47.5%) received intrathecal chemotherapy.Kaplan-Meier analysis showed that the median overall survival(OS) was 26 months.The 2-year survival was 57.5%.The complete response(CR) rate of HD-MTX combined with radiotherapy was 73.3%,with an median survival time of 38.5 months and a 2-year survival of 80.6%.CONCLUSIONS: HD-MTX combined with radiotherapy can improve the clinical outcome of PCNSL.Age and KPS are prognostic factors for PCNSL patients.
出处 《中国神经肿瘤杂志》 2011年第1期21-25,共5页 Chinese Journal of Neuro-Oncology
关键词 中枢神经系统淋巴瘤 化疗 放疗 预后 Central nervous system lymphoma Chemotherapy Radiotherapy Prognosis
  • 相关文献

参考文献14

  • 1Delia Kurzwelly,Martin Glas,Patrick Roth,Elke Weimann,Hanns Lohner,Andreas Waha,Martin Schabet,Guido Reifenberger,Michael Weller,Ulrich Herrlinger.Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status[J]. Journal of Neuro - Oncology . 2010 (3)
  • 2Ferreri AJ,Reni M,Foppoli M,et al.High-dosecytarabine plus high-dose methotrexate versus high-dosemethotrexate alone in patients with primary CNSlymphoma:a randomised phase 2 trial. The Lancet . 2009
  • 3Illerhaus G,Marks R,Muller F,et al.High-dose methotrexate combined with procarbazine and CCNU forprimary CNS lymphoma in the elderly:results of aprospective pilot and phase II study. Annals of Oncology . 2009
  • 4Sierra del Rio M,Rousseau A,Soussain C,et al.Primary CNS Lymphoma in immunocompetent Patients. The Oncologist . 2009
  • 5Batchelor T,Loefller J S.Primary CNS lymphoma. Clinon-col . 2006
  • 6GD Shah,J Yahalom,DD Correa.Combined immunochemotherapy with reduced whole-brain radiotherapy for newly diagnosed primary CNS lymphoma. Journal of Clinical Oncology . 2007
  • 7Gavrilovic IT,Hormigo A,Yahalom J,et al.Long-term follow-up of high-dose methotrexate-based therapy with and without whole brain irradiation for newly diagnosed primary CNS lymphoma. Journal of Clinical Oncology . 2006
  • 8Panageas,K.S.,Elkin,E.B.,DeAngelis,L.M.Trends in survival from primary central nervous system lymphoma, 1975–1999. Cancer . 2005
  • 9Bessell EM,Lopez-Guillermo A,Villa S,et al.Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments. Journal of Clinical Oncology . 2002
  • 10Katherine SP,Elena BE,Leah BP,et al.Patterns of Treatment in Older Adults With Primary Central Nervous System Lymphoma. Cancer . 2007

同被引文献57

引证文献8

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部