摘要
目的：探讨药物对颅脑伤后血糖水平的影响。方法：采用颅脑外伤液压致伤装置制作颅脑伤动物模型，动态观察药物对血糖水平的影响。结果：（１）地塞米松＋ １０％ 葡萄糖＋ 胰岛素药物组和地塞米松＋ ２０％ 甘露醇＋ 胰岛素组，对颅脑伤后的高血糖具有治疗作用。（２）单纯应用２０％ 甘露醇，在７２ ｈ 内对颅脑伤大鼠具显著的降血糖作用。（３）纳络酮能够显著降低颅脑伤大鼠的血糖含量，给药后２４ ｈ 作用最为显著，７２ ｈ 时仍能维持很好的疗效。结论：甘露醇、纳络酮和适度的ｐ Ｈ 值，对颅脑伤动物具有降血糖作用。
Objectve: To study the relationship between the drugs and blood sugar(BS) after brain injury. Methods: The effect of usual drugs which treating brain injury(BI) on BS was observed in rats after head injury.Results: (1)The group of dexamethasonum + 10% glucose + insulin, and the group of dexamethasonum + 20% mannitolum + insulin were effective for treating high BS after drug injection. (2)20% mannitolum was effective for treating high BS after drug injection. (3)Naloxone could markedly decrease BS. Conclusion: The drugs of mannitolum, naloxone and certain pH could decrease blood sugar in brain injury animals
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第8期563-564,共2页
Academic Journal of Second Military Medical University
基金
军队"八五"医学科研规划基金
关键词
颅脑损伤
血糖
小鼠
药物疗法
brain injuries
blood sugar [Acad J Sec Mil Med Univ, 1999, 20(8): 563～564]
