摘要
目的研究血管支架置入术后再狭窄防治的最新进展。方法从药物洗脱支架、血管腔内照射、药物治疗及间充质干细胞四方面总结防治血管支架置入术后再狭窄研究进展。结果 4种方法都可以降低置入血管支架术后的再狭窄发生率。虽然许多防治再狭窄的实验研究效果明显,但由于存在诸如安全性、动物模型、实验方法等一系列问题,临床疗效并不十分满意。结论再狭窄的防治研究应充分考虑导致其发生的诸多因素和环节,尽可能同时打断导致再狭窄的多个环节或因素的作用,以期更有效地防治其发生与发展。
Objective To study the prevention and treatment of restenosis after the stent placement in the latest progress.Methods There were four methods including drug-eluting stents,intracavitary illuminate,drug therapy,and mesenchymal stem cells,which prevented or treatment restenosis after stent placement.Results All the four methods could reduce the postoperative restenosis rate after interventional treatment.Many experimental study of prevention and treatment of restenosis had obvious effect,but clinical curative effect was not very satisfactory,because of a series of problems such as safety,animal models,experiment method,and so on.Conclusion The multiple factors and links caused restenosis should be considered fully,and interrupting the links or factors as far as possible could control the occurrence or development effectively.
出处
《中国普外基础与临床杂志》
CAS
2011年第5期564-567,共4页
Chinese Journal of Bases and Clinics In General Surgery
关键词
术后再狭窄
药物洗脱支架
间充质干细胞
防治
Postoperative restenosis
Drug-eluting stent
Mesenchymal stem cell
Prevention and treatment
