摘要
目的：观察血管内皮生长因子（ Ｖ Ｅ Ｇ Ｆ）在动脉粥样硬化斑块中的表达。方法： 利用高胆固醇饲料复制兔动脉粥样硬化模型，采用免疫组织化学方法，观察 Ｖ Ｅ Ｇ Ｆ在胸主动脉粥样硬化斑块中的表达。结果：正常兔主动脉组织中未见 Ｖ Ｅ Ｇ Ｆ蛋白阳性表达，而动脉粥样硬化斑块区 Ｖ Ｅ Ｇ Ｆ蛋白表达明显增加。结论：动脉粥样硬化斑块中 Ｖ Ｅ Ｇ Ｆ表达增加，并可能参与动脉粥样硬化发生和发展的病理过程。
Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in atherosclerotic plaques.Methods: The rabbit atherosclerotic model was developed by high cholesterol feeding.The VEGF protein level in atherosclerotic plaques were studied by means of immunohistochemistry.Results:VEGF protein was not detected in normal rabbit aortic arteries,the increased production of VEGF protein were found in atherosclerotic plaques.Conclusion:VEGF protein have a high level expression in atherosclerotic plaques and may involve the pathogenesis and progression of atherosclerosis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第9期669-671,共3页
Academic Journal of Second Military Medical University
关键词
动脉粥样硬化
斑块
VEGF
兔
vascular endothelial growth factor
atherosclerosis
