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高通量血液透析对维持性血液透析患者微炎症状态的影响 被引量:34

Changes of microinflammatory state in hemodialysis patients using high-flux membrane dialyzer
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摘要 目的前瞻性研究高通量血液透析对患者微炎症状况的影响。方法前瞻性、自身对照研究。30例维持性常规低通量血液透析患者转换为高通量血液透析12个月。治疗0个月(治疗前)、6个月、12个月分别测定血中高敏C反应蛋白、白细胞介素1和白细胞介素6。结果转换为高通量透析12个月后,血清白细胞介素6水平明显下降(P<0.05),高敏感C反应蛋白和白细胞介素1水平较前无明显变化。结论长时间高通量血液透析不会加剧透析患者体内微炎症状态,而且可能对微炎症状态有一定改善作用。 Objective This is a prospective and self-controlled study designed to detect whether the microinflammatory state improves in hemodialysis patients using high-flux dialysis. Methods Thirty patients on maintenance low-flux hemodialysis were included in this study. They were then switched the dialyzer from low-flux dialyzer to high-flux F60 or FX60 dialyzer without changes of dialysis prescription. Serum high sensitivity C-reactive protein (hCRP), interleukin-1 (IL-1), interleukin-6 (IL-6) and albumin were determined after the switch for 0, 6 and 12 months. Results After the switch from low-flux hemodialysis to high-flux hemodialysis for 12 months, serum hCRP and IL-1 remained unchanged. Serum IL-6 was (39.97±41.03)ng/L, (36.81±37.09)ng/L and (15.17±1.54)ng/L (P0.05) after the switch for 0, 6 and 12 months, respectively. Conclusions Switch from low-flux hemodialysis to high-flux hemodialysis may ameliorate the microinflammatory state in maintenance hemodialysis patients.
出处 《中国血液净化》 2011年第3期133-135,共3页 Chinese Journal of Blood Purification
基金 西城区卫生局科技新星培养项目
关键词 高通量血液透析 高敏C反应蛋白 白细胞介素1 白细胞介素6 High flux hemodialysis High sensitivity C-reactive protein Interleukin-1 Interleukin-6
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参考文献12

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