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心脏型脂肪酸结合蛋白在急性肺栓塞危险分层中的临床价值 被引量：4

Clinical value of heart-type fatty acid-binding protein in risk stratification of acute pulmonary embolism
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摘要 心脏型脂肪酸结合蛋白（H-FABP）是一种敏感性极高的早期心肌损伤标记物,已被论证可用于急性冠脉综合征的诊断和风险评估.本文综述了近年来H-FABP应用于急性肺栓塞（APE）危险分层的临床前瞻性试验并得出结论,H-FABP可以应用于肺栓塞的危险分层,特别对于非高危组肺栓塞患者,H-FABP与肺栓塞患者预后,不管是短期预后还是长期预后都有着很好的相关性. Heart -type fatty acid - binding protein （H - FABP） is an early, highly sensitive marker of myocardial injury, which can be used for the diagnosis and risk assessment of patients with acute coronary syndromes. This review summarizes the clinical prospective studies of H - FABP for risk stratification of acute pulmonary embolism （ PE）, which shows that H - FABP is a useful tool for risk stratification in patients with PE, especially for non - high - risk group. H - FABP is a reliable predictor of short - term or long - term outcome of patients with PE.
作者 李辉(综述) 马青变(审校)
机构地区 北京大学第三医院急诊科
出处 《中国急救医学》 CAS CSCD 北大核心 2011年第5期464-467,共4页 Chinese Journal of Critical Care Medicine
关键词 急性肺栓塞(APE) 心脏型脂肪酸结合蛋白(H-FABP) 危险分层 Acute pulmonary embolism （APE） Heart -type fatty acid -binding protein （ H - FABP） Risk stratification
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献17

  • 1Torbicki A,Perrier A,Konstantinides SV,et al.Guidelines on the diagnosis and management of acute pulmonary embolism:The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology(ESC)[J].Eur Heart J,2008,29(18):2276-2315.
  • 2Alhadi HA,Fox KA.Do we need additional markers of myocyte necrosis:the potential value of heart-acid-binding protein[J].QJM,2004,97(4):187-198.
  • 3Ishii J,Ozaki Y,Lu J,et al.Prognostic value of serum concentration of heart-type fatty acid-binding protein relative to cardiac troponin T on admission in the early hours of acute coronary syndrome[J].Clin Chem,2005,51(8):1397-1404.
  • 4Kilcullen N,Das R,Morrell C,et al.Heart-type fatty acid-binding protein predicts long-term mortality in troponin-negative patients with acute coronary syndrome[J].Circulation,2005,112(SupplⅡ):Ⅱ388.
  • 5Nagahara D,Nakata T,Hashimoto A,et al.Early positive biomarker in relation to myocardial necrosis and impaired fatty acid metabolism in patients presenting with acute chest pain at an emergency room[J].Circ J,2006,70(4):419-425.
  • 6Bertinchant JP,Polge A.Diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP),an early biochemical marker of myocardial injury[J].Arch Mal Coeur Vaiss,2005,98(12):1225-1231.
  • 7O'Donoghue M,de Lemos JA,Morrow DA,et al.Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes[J].Circulation,2006,114(6):550-557.
  • 8Kaczynska A,Pelsers MM,Bochowicz A,et al.Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism[J].Clin Chim Acta,2006,371(1-2):117-123.
  • 9Puls M,Dellas C,Lankeit M,et al.Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism[J].Eur Heart J,2007,28(2):224-229.
  • 10孙晓义,刚丽,张新莉,寇露鑫.心脏型脂肪酸结合蛋白与急性肺栓塞预后相关性的研究[J].大连大学学报,2009,30(3):110-112. 被引量：1

二级参考文献14

  • 1GOLDABER S Z, HAIRE W Alteplase plus heparin in D, FELDSTEIN M L, et al acute pulmonary embolism randomized trail assessing right ventricular function and pulmonary perfusion. Lancet, 1993, 341:507 - 511.
  • 2KASPER W, KONSTANTINIDES S, GEIBEL A, et al. Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism. Heart, 1997,77:346 -349.
  • 3KONSTANTINIDES S, GEIBEL A, OLSCHEWSKI M, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism. Circulation, 1997, 96:882 - 888.
  • 4WOLFE M W, LEE R T, FELDSTEIN M L, et al. Prognostic significace of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J, 1994, 127 : 1371 - 1375.
  • 5GOLDHABER S Z, VISANI L, DE - ROSA M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry. Lancet, 1993, 353 : 1386 - 1389.
  • 6ALHADI H A, FOX K A. Do we need additional markers of myocyte necrosis: the potential value of heart fatty - acid - binding protein. QJM, 2004, 97(4) : 187 -198.
  • 7The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology. Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal , 2005, 29, 2276 - 2315.
  • 8COMA - CANELLA I, GAMALLO C, MARTINEZ O P, et al. Acute right ventricular infarction secondary to massive pulmonary embolism. Eur Heart J ,1988, 9:534 - 540.
  • 9JERJES - SANCHEZ C, RAMIREZ - RIVERA A, LOURDES G M, et al. Streptokinase and heparin versus heparin alone in massive pulmonary embolism: a randomized controlled trial. J Thromb Thrombolysis, 1995, 2:227 - 229.
  • 10MULLER - BARDORFF M, WEIDTMANN B, GIANNITSIS E et al. Release kinetics of cardiac troponin T in survivors of confirmed severe pulmonary embolism. Clin Chem, 2002, 48, 673 - 675.

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二级引证文献18

中国急救医学
2011年 第5期

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