摘要
目的:研究香椿子总多酚对糖尿病小的降血糖作用。方法:一次性ip链脲佐菌素制造糖尿病模型。将香椿子总多酚分低、中、高剂量组(60,801,00 mg·kg-1)连续ig 14 d,第15 d用葡萄糖氧化酶法测空腹血糖,同时测定多酚对正常小鼠血糖影响。糖尿病小鼠处死后取脏器,测定小鼠脏器指数、肝脏超氧化物歧化酶(SOD)活性,丙二醛(MDA)含量变化。结果:香椿子总多酚能降低链脲佐菌素诱导的糖尿病小鼠的血糖,对正常小鼠血糖没有降低作用。香椿子多酚能降低糖尿病小鼠肝脏脏器指数(P<0.05),降低肝脏MDA含量(P<0.05),增加SOD活性(P<0.05)。结论:香椿子多酚对链脲佐菌素所致糖尿病模型小鼠有降血糖作用。
Objective：To study hypoglcemic effect of total polyphenols from seeds of Toona sinensis（STP）on diabetic mice model.Method：Diabetic model was induced by once intraperitoneal injection of STZ.Diabetic mice were randomly divided into model group,Metformin group and high-,middle-and low-doses of STP groups（100,80,60 mg·kg-1）.All groups were fed for 14 consecutive days,and then the blood glucose were detected by glucose oxidizes on the fifteenth day.The organ index was also detected.Result：The blood glucose level of the diabetic mice was significantly decreased.STP could increase liver index significantly（P0.05）.STP could decrease MDA（P0.05） and increase SOD（P0.05） in liver homogenate of the diabetic mice significantly.Conclusion：STP can significantly decrease the blood glucose level in mice with diabetes induced by STZ.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第11期169-171,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
宜昌市科技局基金项目(A2007302-06)
关键词
香椿子
总多酚
降血糖
糖尿病模型小鼠
Toona sinensis
total flavonoid
hypoglycemic effect
diabetic mice
