摘要
［目的］探讨放疗、化疗、激光治疗等综合治疗措施对阴道癌的疗效及其毒副作用。［方法］1985年8月～1995年7月山东省肿瘤医院收治46例原发性阴道癌患者，全部采用60Co体外照射加腔内后装治疗，12例先以VPC方案化疗两个周期，4例因局部病灶较大，采用YAG激光治疗后行化疗和放疗。［结果］所有病例均随访3年以上，46例病人Ⅱ、Ⅲ期的3年生存率分别为66.7％（4／6）、55.0％（22／40），5年生存率分别为50.0％（3／6）、42.5％（17／40）。放射性外阴炎11例，放射性直肠炎4例，放射性膀胱炎2例，直肠阴道疾1例，未控2例。［结论］中、晚期阴道癌的治疗应采用以放疗为主的综合治疗，只要操作适当，多数患者能取得满意疗效，而且放疗并发症不高。
[Purpose]To investigate the effect and toxicity of radiotherapy combined with chemotherapy or(and) lasertherapy for vaginalcarcinoma. [Method]From Aug. 1985 to Jul. 1995,46 patients with vaginal carcinoma were treated in Shandong Cancer Hopial, all patients weregiven 60Co extemal radiation and intracavitary afteloading treatment. Out of 46, 12 cases received 2 cycles of chemothempy of VPC regimen(VCR,PDD, CTX) before radiotherapy,4 cases naived YAG laserthempy before chemotherapy and radiotherapy because of local larger tumor. [Results] Allpatients were followed up over 3 years. 3 - year survival rate of 46 cases for stage Ⅱ and Ⅲ was 66.7% and 55.0%, respectively. 5 - yearsurvival rate for stage Ⅱ and Ⅲ was 50.0% and 42. 5%, respectively. Eleven cases of vulvitis and 4 cases of rectitis caused by radiation werefound. There were one case with fistula of vagino - rectum after radiotherapy, and 2 cases with persistent disease. [Conclusions] Combination therapyshould be applied in advanced vaginal carcinoma, most patients can obtain saisfactory effect. The complications caused by radiotherapy is not high.
关键词
阴道肿瘤
放射治疗
化疗
激光疗法
治疗
Vaginal neoplasms Radiotherapy Chemotherapy Lasertherapy
