摘要
目的探讨染色作着丝位点结构（Cd）的变化在肝癌发生过程的意义。方法采用杂色体Cd带技术检测28例肝癌、25例肝硬化及26例正常人染色体Cd结构丢失频率。结果肝癌组Cd结构在总消失率、A和C组染色体中明显高于肝硬化和正常对照组（P＜0．01），在D、E组染色体中亦高于正常组（P＜0．05）。结论肝癌患者外周血细胞染色体Cd结构丢失有增高趋势，提示Cd结构消失率增加是引起肝癌细胞染色体非整倍性畸变的途径之一。
To investigate the variation of centromeric dots(Cd) in patients with hepatocellular carcinoma (HCC) and its relationship to the development of HCC. Mathods Using Cd - banding techmue,we observed the frequencies of Cd loss in peripheral blood sample 28 cases of HCC,25 cases of liver cirrhosis (LC) and 26 cases of normal persons. Rusults The frequencies of Cd loss in all- loss rate,A and C group chromosome in patients with HCC were significantly higher than those in LC and controls (P<0.01),and that in D,E group were higher than controls (P<0.05)too. Conclusions The frequencies of Cd loss in patients with HCC have a increasing tendency. The change is probably one way of causing cell aneuploid.
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第3期149-150,共2页
Journal of Clinical Hepatology
