摘要
探讨阻断乙型肝炎病毒父婴传播的方法。将126例父亲HBsAg、HBeAg均阳性的婴儿根据母亲抗-Hbs情况分为三个观察组，并以母亲HBsAg、HBeAg均阳性而父亲均阴性且无HBV感染史的婴儿60例做对照，分别在出生后给与乙肝免疫球蛋白和乙肝疫苗联合接种，并于1年后分析其免疫保护率和HBV感染率。结果对照组免疫保护率（IPR）为93．33％，HBV感染率为5.0％，而观察组IPR为66.67％，HBV感染率为15．87％，二者差异显著。但孕前母亲已主动免疫成功者，IPR可达94．74％。出生后的联合免疫对父婴传播的婴儿IPR不够理想，而母亲在获得乙肝主动免疫后再怀孕可有效地阻断HBV的父婴传播。
To study the way of blocking the father- child transmission of HBV. 126 infants whose father were positive for both HBsAg and HBeAg were vaccinated with hepatitis B immunoglolubin(HBIg) and hepatitis B vaccine. The immunoprotect rate (IPR) was analysed. The IPR of father-clind transmission of HBV was lower than the IPR of mothor-child transmission of HBV. Among father-child transmission of HBV cases,IPR of the infants whose mother positive for anti-HBs before pregnancy was higher than those whose mother negative for anti - HBs. Our results suggest that successfully passive immunity before preganancy is an important way to block the father child transmission of HBV.
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第3期172-174,共3页
Journal of Clinical Hepatology
关键词
乙型肝炎病毒
父婴传播
免疫保护率
Hepatitis B virus father-child transmission Active/passive immunity Immunoprotect rate
