摘要
目的:系统考察四物汤及其成分配伍的体外抗凝血作用,发现四物汤活血作用的物质基础,为体内动物实验提供参考依据。方法:采用凝血酶原时间(PT),活化部分凝血活酶时间(KPTT)和凝血酶时间(TT)为检测指标,观察四物汤、阿魏酸、川芎嗪、芍药苷对这些指标的影响。结果:体外凝血研究的结果表明四物汤、阿魏酸、川芎嗪、成分组合能延长凝血时间,且作用呈剂量依赖性。阿魏酸、川芎嗪起主要作用,阿魏酸和川芎嗪的成分配伍与四物汤的抗凝血作用没有明显差别。结论:阿魏酸、川芎嗪是四物汤活血作用的物质基础,两者配伍可以代替四物汤的抗凝血作用。
Objective：To observe the blood anticoagulation effects of Si-wu-tang（SWT） and understand the contributions of different constituents to SWT＇s activities.Methods：The action of SWT and its constituents on prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT） were determined.Results：PT,APTT and TT were obviously prolonged in SWT,tetramethyl pyrazine,ferulic acid group,and these changes also observed in group of combined of tetramethyl pyrazine and ferulic acid.Conclusion：Tetramethyl pyrazine and ferulic acid were active constituents of SWT in the effect of anticoagulation.
出处
《中华中医药学刊》
CAS
2011年第6期1393-1394,共2页
Chinese Archives of Traditional Chinese Medicine
关键词
四物汤
阿魏酸
川芎嗪
凝血
Si-wu-tang
ferulic acid
tetramethyl pyrazine
anticoagulation
