摘要
目的:探讨甲酰四氢叶酸钙(CF)解救大剂量甲氨蝶呤(HDMTX)化疗致急性淋巴细胞白血病(ALL)患儿胃肠道黏膜损伤的效果。方法:将25例患儿随机分为观察组13例和对照组12例,两组化疗总量、疗程、准备工作等相同,观察组在12 h静脉滴注完甲氨蝶呤(MTX)后第12小时使用CF解救,对照组在6.5 h静脉滴注完MTX后第29.5小时使用CF解救。观察两组患儿恶心和呕吐程度、口腔黏膜反应程度、反应持续时间。结果:两组患儿化疗后胃肠道反应程度、口腔黏膜反应程度、反应持续时间比较差异均有统计学意义(P<0.01)。结论:24 h静脉滴注MTX后第12小时开始给予CF解救更有利于保护胃肠道和口腔黏膜,促进受损组织细胞修复,提高化疗效果和患儿生存质量,具有较好的临床应用价值。
Objective： To explore the effect of Calcium Folinate（CF） on rescuing acute gastrointestinal mucosal injury induced by chemotherapy with high-dose Methotrexate（MTX） in the children patients with acute lymphoblastic leukemia（ALL）.Methods： 25 children patients were randomly divided into observation group（n=13） and control group（n=12）.The dose of chemotherapy,courses of treatment and preparation were the same in the two groups.In the observation group,CF was used in the 12th hour to rescue the children patients after the intravenous infusion of MTX for 12 hours;in the control group,CF was used in the 29.5th hour to rescue the children patients after the intravenous infusion of MTX for 6.5 hours.The degree of nausea and vomiting,the degree of responsiveness of the oral mucosa and the reaction duration were observed in both groups.Results： There were statistically significant differences in the comparison of gastrointestinal reactions,the degree of responsiveness of the oral mucosa of the patients and the reaction duration between the two groups after the chemotherapy（P〈0.01）.Conclusion： CF was used in the 12th hour to rescue the children patients after the intravenous infusion of MTX for 12 hours is more conducive to the protection of gastrointestinal tract and oral mucosa,to promoting the repair of damaged tissues and cells so as to improve the quality of life of children patients and the effectiveness of chemotherapy.
