摘要
心力衰竭(心衰)是各种心脏疾病发展至最后的临床综合征,心室重塑是心衰进展的重要机制。心肌细胞的丢失和室壁纤维化促进心室重塑。肌钙蛋白T是心肌细胞损伤的特异性标志物。大部分心衰患者血浆中可检测到肌钙蛋白T,提示心衰进展中持续存在慢性心肌损伤。研究表明心衰患者肌钙蛋白T浓度与心衰严重程度及发生不良事件的危险性密切相关,可较准确地提供患者预后信息。肌钙蛋白T可作为预后的一项重要生化标志物。现就肌钙蛋白T对心衰的预后研究做一综述。
Heart failure is a terminal clinical syndrome that develops from heart disease.Ventricular remodeling,which is exacerbated by the loss of myocytes and ventricular fibrillation,is an important mechanism contributing to the progression of heart failure.Cardia troponin T（cTnT） is a biomarker that can be used to determine cardiac damage.cTnT can be detected in the plasma of most heart failure patients,which indicates chronic myocyte damage.It＇s reported that the level of cTnT is closely associated with the degree of heart failure and the risk of cardiac events.Therefore,cTnT is a potential diagnostic marker.This article reviews the prognostic role of cardiac troponin T on the outcome of chronic heart failure.
出处
《心血管病学进展》
CAS
2011年第3期371-373,共3页
Advances in Cardiovascular Diseases
关键词
肌钙蛋白T
慢性心衰
预后
cardiac troponin T
chronic heart failure
prognosis
