摘要
用ＥＬＩＳＡ及ＡＰＡＡＰ法分别检测了３９例乙型肝炎病毒（ＨＢＶ）感染者、１５例有ＨＢＶ感染的肝癌患者及２０例正常人的血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）和外周血Ｔ淋巴细胞亚群。结果显示，肝癌及ＨＢＶ感染者的血清ＳＩＬ－２Ｒ均明显高于正常人（Ｐ＜０．０１），肝癌患者的ＳＩＬ－２Ｒ明显高于ＨＢＶ感染者（Ｐ＜０．０１）。肝癌患者及ＨＢＶ感染者的ＣＤ３、ＣＤ４、ＣＤ８、ＣＤ４／ＣＤ８与对照相比均有显著差异（Ｐ＜０．０５），而肝癌与ＨＢＶ感染者相比无显著差异（Ｐ＞０．０５）。提示ＨＢＶ感染者及肝癌患者均存在细胞免疫功能紊乱，尤以肝癌患者明显；ＣＤ４、ＣＤ４／ＣＤ８下降可能是引发肝癌的基础；血清ＳＩＬ－２Ｒ显著升高可能是肝癌发生的重要原因，也是ＨＢＶ感染者可能发生癌变的重要指标。
T lymphocyte subsets and soluble Interlukin 2 receptor(SIL 2R)were measured by ELISA and APAAP in 39 cases Hepatitis B,15 cases liver cancer and 20 health controls Results showed that the level of SIL 2R and the positive rates of CD 3,CD 4,CD 8 in Hepatitis B and liver cancer were significantly higher than that of the health controls(P<0 01,P<0 05) The SIL 2R level in liver cancer was much higher than that of the Hepatitis B(P<0 01),but the positive rates of CD 3、CD 4、CD 8 were found no marked difference between them(P>0 05) These results suggest that the cell immunological function of Hepatitis B and liver cancer was disorder,especially in the liver cancer The decrease of CD 4 positive rate and the increase of SIL 2R level may play an important role in the development of liver cancer,also an important marker for predicting the carcinogenesis of Hepatitis B
出处
《山东医药》
CAS
北大核心
1999年第15期7-8,共2页
Shandong Medical Journal
关键词
肝肿瘤
乙型肝炎
SIL-2
T细胞亚群
Liver cancer Patient infected with HBV Soluble Interlukin 2 receptor T lymphocyte subsets
