摘要
应用免疫组织化学技术检测10例正常子宫内膜、22例不典型增生和42例子宫内膜癌组织P16蛋白的阳性表达率。结果显示,子宫内膜癌组织P16蛋白阳性表达率为69%,低于正常子宫内膜(100%)和不典型增生组织(91%);高分化肿瘤的P16蛋白阳性表达率高于低分化者,但P16蛋白的阳性表达率与子宫内膜癌临床分期无关;子宫内膜癌患者P16蛋白表达阴性者较阳性者预后差。提示P16基因可能参与子宫内膜癌的发生,P16蛋白表达可作为预测子宫内膜癌患者预后的一个重要指标。
Immunohistochemistry was used to detect the expression of P 16 protein in 10 cases of normal endometrium,22 cases of atypical hyperplasia,and 42 cases of endometrial carcinoma The results showed that the positive expression rate(69%)of P 16 protein in endometrial carcinoma was lower than that in normal endometriums(100%)and atypical hyperplasias(91%),and the positive expression rate of P 16 protein in high differentiating tumors was higher than that in low differentiating tumors However the expression of P 16 protein was not correlated with the surgical staging of endometrial carcinoma The prognosis of patients with P 16 protein negetive expression was poor It suggest that the inactivation of P 16 gene may be involved in the carcinogenesis of endometrial carcinoma,and the expression of P 16 protein may be a useful prognosticator of endometrial carcinoma
出处
《山东医药》
CAS
北大核心
1999年第15期13-14,共2页
Shandong Medical Journal