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TNF-α对银屑病患者成纤维细胞基因表达的影响 被引量：2

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摘要 目的:探讨银屑病患者皮肤成纤维细胞在TNF-α作用下基因表达的变化。方法:体外培养银屑病患者皮肤成纤维细胞,以TNF-α刺激为实验组,以正常培养为对照组;用GeneChip Human Genome U133 Plus2.0芯片分析TNF-α作用下成纤维细胞基因表达情况。结果:差异表达基因共有730条,其中上调基因395条,下调335条。差异基因主要参与合成、分解、加工修饰、代谢、运输、调控、分子复合、信号传导、细胞周期与细胞凋亡、发育、免疫等过程。结论:运用基因芯片技术研究成纤维细胞在TNF-α作用下基因表达的变化,可能为探讨银屑病的病因和发病机理的研究提供新的思路。
作者 徐皓 程随涛 张衍国 吕雅洁 张惠中 余春艳
机构地区 武警陕西总队医院 第四军医大学唐都医院
出处 《陕西医学杂志》 CAS 2011年第6期674-675,684,共3页 Shaanxi Medical Journal
关键词 银屑病 成纤维细胞 肿瘤坏死因子-Α 基因表达调控
分类号 R785.63 [医药卫生—口腔医学]
  • 相关文献

参考文献9

  • 1李海红,周岗,付小兵,屈振亮,孙同柱,顾绍峰.人皮肤成纤维细胞的培养和鉴定[J].中国危重病急救医学,2005,17(2):89-91. 被引量：17
  • 2Dasu MR,Hawkins HK,Barrow RE,et al.Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation[J].J Pathol,2004,202:476-485.
  • 3Zalewska A,Glowacka E,Wyczolkowska J,et al.Sysa-Jedrzejowska,Interleukin 6 and 8 levels in plasma and fibroblast cultures in psoriasis[J].Mediators Inflamm,2006,81:767.
  • 4Kovacs D,Falchi M,Cardinali G,et al.Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis[J].Exp Dermatol,2005,(14):130-137.
  • 5赵小东,付萌,卢涛,孙林潮,廖文俊,王冬青,刘玉峰.银屑病成纤维细胞培育上清对角质形成细胞增殖的影响[J].中华现代皮肤科学杂志,2004,1(2):103-105. 被引量：2
  • 6张国龙,张胜权,严开林,吴学平,范星,王剑,贾雪梅,杨森,刘建军,张学军.IL-15在寻常型银屑病患者皮损中的表达[J].安徽医科大学学报,2006,41(4):450-453. 被引量：3
  • 7Sjursen W,Brekke OL,Johansen B.Secretory and cytosolic phospholipase A(2)regulate the long-term cytokine-induced eicosanoid production in human keratinocytes[J].Cytokine,2000,(12):1189-1194.
  • 8Weaver LK,Pioli PA,Wardwell K,et al.Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors[J].J Leukoc Biol,2007,(18):663-671.
  • 9Fujimoto Y,Tu L,Miller AS,et al.CD83 expression influences CD4+ T cell development in the thymus[J].Cell,2002,108:755-767.

二级参考文献15

  • 1Krueger J G, Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis[ J ]. Ann Rheum Dis, 2005,64 (Suppl 2) :ii30 - 6.
  • 2Liew F Y,Mclnnes I B. Role of interleukin 15 and interleukin 18 in inflammatory response[ J]. Ann Rheum Dis, 2002, 61 (Suppl Ⅱ ) : ii100 - ii102.
  • 3Bulfone-Pau S S, Bulanova E, Pohl T, et al. Death deflected: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15R chainα[J]. FASEB J, 1999, 13(12) :1575 - 85.
  • 4Grabstein K H, Eisenman J, Shanebeck K, et al. Cloning of a T cell growth factor that interacts withthe beta chain of the interleukin-2 receptor[J]. Science, 1994, 264(5161 ): 965 -8.
  • 5Onu A, Pohl T, Krause H, et al. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms [ J]. J Immunol,1997, 158(1) : 255 -62.
  • 6Kurys G, Tagaya Y, Bamford R, et aL The Long Signal Peptide Isoform and Its Alternative Processing Direct the lntracellular Trafficking of lnterleukin-15 [ J ]. J Biol Chem, 2000, 275 ( 39 ) :30653 - 9.
  • 7Gaggero A, Azzarone B, Andrei C ,et al. Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms[ J]. Eur J Immunol, 1999, 29(4) : 1265 -74.
  • 8Ruckert R, Asadullah K, Seifert M, et al. Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis[J]. J Immunol, 2000, 165(4) :2240 -50.
  • 9Leroy S, Dubois S, Tenaud I, et al. lnterleukin-15 expression in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) [J]. Br J Dermatol, 2001, 144(5):1016-23.
  • 10Zhang X J, He P P, Wang Z X, et al. Evidence for a major psoriasis susceptibility locus at 6p21 ( PSORS1 ) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans[J]. J Invest Dermatol, 2002, 119(6) :1361 -6.

共引文献19

同被引文献20

  • 1Ottaviani C,Nasorri F,Bedini C. CD56bright CD16-NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation[J].European Journal of Immunology,2006,(01):118-128.
  • 2Wetering D,Paus RA,Dissel JT. IL-23 modulates CD56+/CD32-NK cell and CD56+/ CD3+ NK-like T cell function differentially from IL-12[J].International Immunology,2008,(02):145-153.
  • 3Colonna M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity[J].Immunity,2009,(01):15-23.
  • 4Pietrzak AT,Zalewska A,Chodorowska G. Cytokines and anticytokines in psoriasis[J].Clinica Chimica Acta,2008,(1-2):7-21.
  • 5Gudjonsson JE,Karason A,Antonsdottir AA. HLA-Cw6-positive and HLA-Cw6-negative patients with psoriasis vulgaris have distinct clinical features[J].Journal of Investigative Dermatology,2002,(02):362-365.
  • 6Dunphy S,Gardiner CM. NK cells and psoriasis[J].Journal of Biomedicine and Biotechnology,2011.ArticleID248317,10psges.
  • 7Seino K,Taniguchi M. NKT cells:a regulator in both innate and acquired immunity[J].Curr Med Chem-Anti-Inflammatory & Anti-Allergy Agents,2005,(01):59-64.
  • 8Cameron AL,Kirby B,Fei W. Natural killer and natural killer-T cells in psoriasis[J].Archives of Dermatological Research,2002,(08):363-369.
  • 9Curry JL,Qin JZ,Robinson J. Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model system[J].Archives of Pathology and Laboratory Medicine,2003,(03):289-296.
  • 10Koreck A,Surányi A,Sz(o)ny BJ. CD3+ CD56+ NK T cells are significantly decreased in the peripheral blood of patients with psoriasis[J].European Journal of Immunology,2006,(01):118-128.

引证文献2

二级引证文献4

陕西医学杂志
2011年 第6期

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