摘要
应用免疫组织化学（ＳＡＢＣ法） 和核酸原位杂交技术检测了正常人皮肤、皮肤鳞状细胞癌中热休克蛋白７２ 的表达情况。结果显示，ＨＳＰ７２ 在正常皮肤的表皮层及毛囊外根鞘即有构成性表达， 可能是一种自身保护功能。ＨＳＰ７２ 在皮肤鳞癌中高表达， 可能通过影响细胞生长调控而在肿瘤发生、发展过程中具有重要作用。
With immunohistochemistry (Strepavidin Biotin Complex) and in situ hybridization technique, we detected the expression of 72 kD heat shock protein(HSP72) in normal skin and cutaneous squamous cell carcinoma. The results showed that HSP72 was constitutively expressed in the epidermis and outer root sheath of the normal skin, suggesting that HSP72 may be involved in the protective function of normal human skin. A high degree of HSP72 expression was observed in cutaneous squamous cell carcinoma, suggesting that HSP72 may play an important role in oncogenesis by influencing the cellular growth control.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1999年第4期225-227,共3页
Journal of Clinical Dermatology
关键词
热休克蛋白
皮肤鳞状细胞癌
原位杂交
Heat shock protein Cutaneous squamous cell carcinoma Immunohistochemistry In situ hybridization
