摘要
目的观察黄蜀葵花对慢性肾小球肾炎患者肾小管功能的影响,揭示其对肾小球疾病患者的肾小管保护作用。方法将我院2008年1月至2010年5月慢性肾小球肾炎住院患者229例纳入本研究,黄蜀葵花治疗组168例,对照组61例,观察2组患者治疗前后血清肌酐水平(Scr)、估算的肾小球滤过率(eGFR)、尿α1-微球蛋白(α1-MG)、尿N-乙酰-β-氨基葡萄糖苷酶(NAG)、尿比重(SG)等指标变化情况。结果治疗2个月后黄蜀葵花治疗组肾功能正常患者的尿α1-MG、NAG水平均较治疗前显著下降(P<0.05),尿SG水平较治疗前显著上升(P<0.05),黄蜀葵花治疗组轻度肾功能损害患者的尿α1-MG、NAG和Scr水平均较治疗前显著下降(P<0.05),eGFR较治疗前显著升高(P<0.05)。对照组较治疗前无明显变化(P>0.05),2组比较,P<0.05。结论黄蜀葵花可以降低慢性肾小球肾炎患者尿α1-MG、NAG水平,可以改善肾小管功能,延缓慢性肾衰竭进展。
OBJECTIVE To observe the effect of abelmoschu manihot on renal tubular function in patient with chronic glomerulonephritis,and reveal its protective function on renal tubules.METHODS 229 chronic glomerulonephritis patients in our hospital（from January in 2008 to May in 2010） were divided into two groups：treatment group（168 cases） and control group（61 cases）.The levels of serum creatinine（Scr）,estimated glomerular filtration rate（eGFR）,urine α1 microglobuli（α1-MG）,urine N-Acety1-β-glucosaminase（NAG） and urine specific gravity（SG） before and after the treatment were observed.RESULTS After two-month treatment,the levels of urine α1-MG and urine NAG of patients with normal renal function in treatment groups decreased significantly（P0.05） and urine SG increased significantly（P0.05）.The levels of urine α1-MG,urine NAG and Scr of patients with slight renal function impairment decreased significantly（P0.05）;the level of eGFR increased significantly（P0.05）.There was no significant change（P0.05）.CONCLUSION Abelmoschus manihot can reduce the levels of urine α1-MG,urine NAG of patients with chronic glomerulonephritis,improve the function of renal tubules and retard the progression of renal failure.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2011年第3期293-294,共2页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
黄蜀葵花
肾小球肾炎
肾小管间质
abelmoschus manihot
glomerulonephritis
tubulointerstitium
