摘要
目的 寻找硒拮抗氟毒作用的最佳作用浓度及氟中毒的敏感且无损伤监测指标。方法 研究饮水中加入不同浓度的Ｎａ２ＳｅＯ３（０，０．５，２．０，４．０ｍ ｇ／Ｌ）对同时加入的ＮａＦ（１５０ｍ ｇ／Ｌ）所致ＳＤ大鼠肾脏损害的影响，实验期７０ 天。结果 氟组大鼠血清ＬＰＯ 含量及７０ 天时肾组织ＬＰＯ含量显著升高，同时尿液中γ－ＧＴ、ＮＡＧ、ＡＫＰ在３５、５０ 和７０ 天时较对照组显著升高。饮水中２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 对ＮａＦ所致尿酶以及血清和肾组织ＬＰＯ 含量升高具有明显拮抗作用，４．０ｍ ｇ／ＬＮａ２ＳｅＯ３ 本身表现出一定的毒性作用。此外发现饮水中０．５ 和２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 可使大鼠８ 小时尿氟排泄量在７０ 天时显著上升（ Ｐ＜ ０．０５ 和Ｐ ＜ ０．０１）。结论 对于饮水中１５０ｍ ｇ／Ｌ ＮａＦ所致肾脏损害，２．０ｍ ｇ／Ｌ Ｎａ２ＳｅＯ３ 为最佳拮抗浓度。
Objective To explore the optimal level of selenium against fluoride toxicity and noninvasive indicators sensitive for the detection of fluorosis.Methods The effect of different concentrations of Na 2SeO 3 (0,0.5,2.0,4.0mg/L) in drinking water on the renal impairments of S.D. male rats induced by NaF (150mg/L) were studied for 70 days.Results The content of Lipid Peroxide (LPO) in kidney at the 70th day and those in serum were significantly increased by NaF.In addition,the marked increases of activities of γ GT,NAG and AKP in urine were observed at the 35th,50th and 70th day.2.0mg/L Na 2SeO 3 in drinking water possessed obvious antagonism against the increases of urinary enzymes and the content of LPO both in serum and kidney,whereas 4.0 mg/L Na 2SeO 3 presented some toxicity by itself.It is also found that the amount of F in 8hour urine increased significantly with the presence of 0.5 and 2.0mg/L Na 2SeO 3.Conclusions 2.0mg/L Na 2SeO 3 is the optimal concentration against the renal impairments induced by 150mg/L NaF in drinking water. [
出处
《中国地方病学杂志》
CAS
CSCD
1999年第6期411-414,共4页
Chinese Jouranl of Endemiology
基金
国家教委科研基金
关键词
硒
氟
最佳拮抗浓度
尿酶
肾损伤
氟中毒
地方性
Selenium
Fluoride
Optimal Concentration
Urinary Enzyme
Lipid Peroxide
