摘要
酪氨酸激酶在肿瘤的发生、发展过程中起着非常重要的作用,已成为肿瘤治疗的新靶点。嘧啶类化合物是蛋白酪氨酸酶抑制剂(PTKIs)中的一大类,这类化合物在临床前期研究中显示具有很好的抗肿瘤效应,一些已在临床上作为很有前景的抗癌药。本文按其结构类别介绍了近年来报道的嘧啶类酪氨酸激酶抑制剂。
Protein Tyrosine Kinase Inhibitors(PTKIs) play critical roles in the process of cancer development and have become new target for tumor treatment.Pyrimidines are one large class of PTKIs.They have shown good antitumor effect in preclinical studies.Some of them have been promising anti-cancer drugs in clinical use.The development of PTKIs of Pyrimidines is introduced according to their structures.
出处
《化学通报》
CAS
CSCD
北大核心
2011年第6期528-533,共6页
Chemistry