摘要
目的探讨液基薄层细胞检测(TCT)结合高危型人乳头瘤病毒(HPV)体检筛查在宫颈上皮内瘤变及宫颈癌防治过程中的作用。方法 2009年7月—2010年7月濮阳市油田总医院门诊接受宫颈癌筛查的763名妇女分别进行高危型HPV及TCT检查,任何一项或两项同时阳性患者均行阴道镜下多点活检病理学检查。比较三种检查方法阳性病例与病理检查结果符合率。结果 763名妇女中,高危型HPV检出阳性287例,占37.6%,经病理学检查阳性82例,阳性符合率为28.6%;TCT检出阳性78例,占10.2%,病理检查阳性50例,阳性符合率64.1%;高危型HPV加TCT检出两者均阳性129例,与病理检查结果阳性符合率为97.7%,各组之间阳性符合率比较,差异有显统计学意义(P<0.05);高危型HPV在不同宫颈病变中的阳性率分别为宫颈癌前病变(CIN)Ⅰ23.33%(14/60)、CINⅡ42.85%(15/35)、CINⅢ50%(15/30)、SCC 85.7%(6/7)。结论随着宫颈病变级别的升高,高危型HPV-DNA的阳性率显著上升;高危型HPV-联合TCT检查可提高宫颈上皮内瘤变及宫颈癌检出率,为宫颈癌的早期诊断提供参考。
Objective To study the clinical application value of screening cervical precancerous lesions of high risk human papillomavirus（HR-HPV） testing combined with thin-prep cell test,（TCT） in prevention of cervical lesions and cervical cancer.Methods Totally 763 women in our hospital from Jan 2006 to Jan 2010,were screened by HR-HPV test or thin-prep cell test.Directed biopsies under colposcopy were taken either positive in any test or both two.We compared the postive coincident rate with the the pathology test positive rate during the three technologies.Results HR-HPV positive was 287 in 763 cases,the rate of infection was 37.6%,and pathology test positive was 82 cases,the coincident rate of which was 28.6%;TCT positive was 78 cases,the rate of infection was 10.2%,and pathology test positive was 50 cases,the coincident rate of which was 64.1%;HR-HPV＋TCT positive was 129 cases,and the coincident rate of infection was 97.7% in pathology test.Among each coincident rate,the differences were statistical significant（P0.05）.The rate of HR-HPV infection CINⅠwas 23.33%（14/60）,CINⅡ42.85%（15/35）,CINⅢ50%（15/30）,SCC 85.7%（6/7）,respectively.Conclusions The positive rate of HR-HPV DNA increases significantly with the grade of cervical precancerous lesions.It is of great significance to screen in the population for HPV and TCT in a regular time span,since it could not only lower the HPV infection rate and decrease the incidence of cervical lesions,but also prevent the cervical cancer.
出处
《医药论坛杂志》
2011年第7期78-80,共3页
Journal of Medical Forum
关键词
HPV
液基细胞学检测
宫颈上皮内瘤变
宫颈癌
防治
Human papillomavirus
Thin-prep cell test
Intraepithelial neoplasia
Cervical cancer
Prevention
