摘要
目的：探讨COX-2在宫颈癌中的表达及与临床病理的关系.方法：采用免疫组织化学SP法检测20例正常宫颈、30例CIN 及61例宫颈癌组织中COX-2的表达.应用SPSS17.0统计软件,采用X2检验和Mann-Whiteney 检验进行统计分析,P〈0.05为差异有统计学意义.结果：1.COX-2在正常宫颈、CIN及宫颈癌三种组织中表达存在差异,三组之间总体差异具有显著性,两两比较,表达差异具有统计学意义.2.COX-2在腺癌中阳性表达率为91.67%;COX-2在鳞癌中阳性表达率为87.76%,二者比较差异均具有统计学意义.2.COX-2在宫颈鳞癌中的表达与淋巴结转移、间质浸润深度相关,与临床分期、病灶大小、病理分级之间无显著性差异.结论：1.COX-2在不同宫颈组织中表达不同,随宫颈病变程度加重,COX-2表达增加.2.COX-2在腺癌中的表达高于鳞癌,在宫颈鳞癌中的表达与淋巴结转移、间质浸润深度相关,与临床分期、病灶大小、组织学分级之间无显著差异,提示COX-2可能参与宫颈的侵袭及转移.
Objective;To study the expression of COX--2 in different cervix tissues（normal cervix, cervical intraepithelial neoplasia （CIN）, cervical carcinoma） by Immunohistoehemistry and the relationship with clinical--pathological factors. Methods.. Immunohistochemistry was used to test the expression of COX--2 in normal.CIN and cervical carcinoma respectively.χ2 test and Mann--Whiteney test was used, when P〈0.05,it has statistical significance. Result： 1. COX--2 was absent in normal cervix, while the positive express rate in CIN and cervical carcinoma was 56.67%, 88.52% respectively. The total difference in three groups was significant , the difference in every couple group is significant. 2. The positive expression of COX--2 in adeno- carcinoma was 91.67%. The positive expression af COX--2 in squamous carcinoma was 87.76%. The expression of COX--2 was significantly increased in adenocarcinoma compared with squamous carcinoma. The expression of COX--2 was related to lymph node metastasis.depth of stromal invasion and has no significance in pathological grading, tumor size and clinical stage. Conclusion： 1. The expression of COX--2 in different cervical tissue was significantly. It suggested that COX--2 may be invoved in the develop of cervical cancer. 2. Compared with squamous carcinoma, the expression of COX--2 was significantly increased in adenoeareinoma. The expression of COX--2 was significantly related to lymph node metastasis.depth of stromal invasion, and has no ralationship with pathological grading, tumor size and clinical stage. It suggested that the expression of COX--2 may be related to metastasis and invasion in cervical cancer.
关键词
宫颈癌
宫颈上皮内瘤变
环氧化酶-2
免疫组织化学
Cervical caneer
Cervical intraepithelial neoplasia
Cyclooxygenase--2
Immunohistoelaemistry
