摘要
以单硬脂酸甘油酯为载体,应用乳化-溶剂挥发法制备醋酸地塞米松纳米粒,测定其粒径、药物包封率等性质。经过正交优化试验确定其优选方案为:载体材料单硬脂酸甘油酯的用量为0.3g,表面活性剂为硬脂酸聚烃氧酯(S-40)/泊洛沙姆(F68)(质量比为7/3)的混合物,有机相氯仿与水相的体积比为5:75,蒸发有机相氯仿时的真空度为0.05MPa。制备所得的醋酸地塞米松纳米粒球体均匀度好,平均粒径在100nm左右,载药纳米粒的包封率在89.03%左右。
Monostearin as carrier, Dexamethasone acetates nanoparticles were prepared by the emulsion-solvent evaporation method and investigated their size and encapsulation efficiency. Various preparation processes of Dexamethasone acetates nanoparticles were carried out and investigated their effect on particle size and encapsulation efficiency. Orthogonal design was applied to optimize the preparation technology on the basis of the single factor evaluation .The optimal conditions for preparing nanoparticles included the dosage of monostearin at 0.3g, the rate of S-40/ F68 at 7/3, the volume rate of O/W at 5/75 （V/V） and the vacuum of solvent - evaporation at 0.05MPa.The prepared Dexamethasone acetates nanoparticles are spherical and discrete particles without aggregation; they are smooth in surface morphology, and their everage size is 100nm,The encapsulation efficiency is aboat 89.03%.
出处
《科技信息》
2011年第15期56-57,共2页
Science & Technology Information
关键词
醋酸地塞米松
纳米粒
单硬脂酸甘油酯
包封率
Dexamethasone acetates
Nanoparticles
Monostearin
Encapsulation efficiency
