期刊文献+

中国发表的中西医结合治疗肝炎后肝硬化随机对照试验的文献评价

Randomized Controlled Trials of Integrated Traditional Chinese and Western Medicine Treatment for Posthepatitic Cirrhosis:Literature Quality Evaluation
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摘要 目的评价中国发表的中西医结合治疗肝炎后肝硬化随机对照研究的概况及质量。方法计算机检索CNKI、万方学术期刊全文数据库、CBM等数据库,对1980年1月~2010年1月正式刊载的121篇入选文献进行Jadad量表评分,对其中记2分以上的39篇肝炎后肝硬化中西医结合随机对照试验(RCT)文献进行综合分析。结果 30年来国内肝炎后肝硬化中西医结合临床治疗性研究主要存在以下几个方面的问题:临床随机对照试验设计不严密,缺乏盲法的使用,缺乏统一规范的研究标准,样本含量低且无具体的估算方法,缺乏依从性、病例脱落及失访情况的分析,忽视不良反应的报告和生活质量的研究。结论肝炎后肝硬化的中西医结合临床治疗具有"个性化""多样化"的特点,临床疗效均优于单纯西医药,但因其临床科研方法的质量及水平存在偏倚,在临床应用上应注意结合医师经验。 To explore the condition and quality of domestic clinical therapeutic studies on integrated traditional Chinese and western medicine for posthepatitic cirrhosis in recent 30 years. Methods Jadad scale was used to score 121 literatures selected from January 1980 to January 2010 in periodicals of domestic authoritative resources da- tabases, such as CNKI, VIP, WanFang Data, and CBM. Systematic reviews were conducted to 39 randomized controlled trials (RCTs) literatures of treating posthepatitic cirrhosis with integrated traditional Chinese medicine and western medicine scored two or more points. Results In 30 years, the main problems existing in domestic posthepatitic cirrhosis clinical research of integrated traditional Chinese and western medicine were as follows: the design of clinical RCTs was not strict enough; there was deficiency in the use of blind method; the standardized and uniformed research standard were insufficiency; the sample content was low without specific estimation methods; there was lack of analyses in compliance with cases falling off or without follow-up; and the report of adverse reaction and the quality of life research was neglected. Conclusion Posthepatitic cirrhosis therapy of integrated traditional Chinese and western medical is of "personalized" and "diversified" characteristics. Its therapeutic effects are significantly better than those of pure western medicine and worthy to be popularized in the clinic, However, the quality and level of its clinical scientific research methods still need further improvement.
出处 《中国循证医学杂志》 CSCD 2011年第6期716-720,共5页 Chinese Journal of Evidence-based Medicine
基金 广东省"211工程"三期重点学科建设项目
关键词 肝炎后肝硬化 中西医结合 随机对照试验 文献质量评价 Posthepatitic cirrhosis Integrated traditional Chinese and western medicine Randomized controlledtrial Literature quality evaluation
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