摘要
目的探讨血清胱抑素C(cystatin,Cys-C)对慢性心力衰竭(CHF)患者的临床评价意义。方法选择2010年7～12月在我院心内科住院的心脏病患者114例,并将其分为A、B、C 3组。A组64例为CHF患者(无原发性肾脏疾病),B组50例为无心力衰竭的心脏病患者,C组58例为健康志愿者。分别测定A、B、C 3组患者Cys-C、血清肌酐(SCr)、尿素氮(BUN)及血清β2-微球蛋白(β2-MG)水平,并进行统计分析。结果 A组与B、C组相比,血Cys-C浓度明显升高(P<0.01),其中心功能Ⅲ、Ⅳ级的血清浓度高于Ⅰ～Ⅱ级(P<0.05);不同病因心力衰竭组相互比较,血CysC浓度差异无统计学意义;血Cys-C与年龄成正相关,与左心射血分数(LVEF)、B型尿钠肽(BNP)水平呈负相关。结论血Cys-C浓度反映CHF患者的早期肾功能损害,可能是心力衰竭恶化的早期指标之一,是评估CHF风险预后的有效指标。
Objective To discuss clinical evaluation of serum cystatin C（Cystatin,Cys-C） concentrations for patients with CHF（Chronic Heart Failure）. Methods 114 patients with heart disease in the Cardiology Department of our hospital from July 2010 to December 2010 were chosen and divided into three groups.Patients in Group A（n=64） had chronic heart failure（no primary renal disease）,Group B（n=50） patients without heart failure,and Group C（n=58） healthy volunteers as control group.Cys-C,serum creatinine （SCr）,blood urea nitrogen（Bun） and serum β2-microglobulin（β2-MG） levels of the three groups were measured respectively,and statistical analysis was done as well.Results Compared with Group B and C,serum CysC concentrations of Group A were significantly increased（P0.01）,its heart function Ⅲ,Ⅳ grade was higher than the serum concentrations of Ⅰ～Ⅱ level（P0.05）.The causes of groups with different heart failure were compared and concentrations of CysC had no significant differences.CysC was positively correlated with age and LVEF,and BNP levels were negatively correlated.Conclusion CysC concentration reflects early renal damage of patients with CHF,and is an early indicator of deteriorating heart failure.It is also an effective indicator to assess the prognosis of CHF risk.
出处
《实用临床医药杂志》
CAS
2011年第9期40-42,46,共4页
Journal of Clinical Medicine in Practice
关键词
心力衰竭
充血性
胱抑素C
血肌酐
heart failure
congestive
cystatin C
serum creatinine
