摘要
操探讨返流性肾病的发病与免疫致病的关系。方法：通过全血体外培养法，对１２例返流性肾病患儿外周血淋巴细胞体外活化，并用流式细胞仪测定淋巴细胞活性化抗原ＣＤ６９、ＣＤ７１和ＨＬＡ－ＤＲ。结果：在分裂原ＰＤＢ或ＰＨＡ刺激下，正常组淋巴细胞与Ｃｏｎｔｒｏｌ组对比，ＣＤ６９＋、ＣＤ７１＋、ＨＬＡ—ＤＲ十显著增殖（Ｐ＜００５），返流性肾病组则无明显差异（Ｐ＞０．０５，ＣＤ６９除外）。结论：返流性肾病存在细胞免疫调节功能失调，与该病发病密切相关。
Objective 7to h-lvestigute tile role of illllll\1:]c ITlecllaflislll ill ti7e patljogrllesis o[ reflux llcI3hl-oljatl3y. Methods Thelyllll)l-locytCS fronl the ltellphellal 13food of 12 cllil(l]'cll xvitll IEflux ]JcIJhrol)atlly able activated 111 vitro by the WllolC bloodeel] ctiltule, then lylnphocytC actiVatioll aTltigClls (Clj69, CD71 aTlcl HLAwDR) weld dctCctecl 1)y flow cytonletlfy. ResultsBy tile stllllulatioTI of tile Antogr13s(PDB or r,11,JI'\), tile ly1TlljllocVte of the llolaria] grotlD could la significantly exDa13dc(lthl-oLlgh CD69, CD71 and HI.A--DI{ cxljl-essi()11 colllliarecl al\l^itll tile colrrtrol groulo (P < 0.01, Hoxvcvel}, there ovas 17odiffoletlce h.l lIN (Tho.05,exciucinlg CD69 ill I)I-l,(\+IJI)I{ gi f(}lll..). I3[)13 groLllJ). COllcluSiolls Tile lesults slloxv a diSbalzlTlcc of'ilrnllullological tldjustillg cells ill ltllux [Ic13111-01illtll}/, xvilicll is lelcvaTIL ic tile patllogellesi-s of ltl'lux llopllroljatlly.
出处
《中国现代医学杂志》
CAS
CSCD
1999年第10期4-5,共2页
China Journal of Modern Medicine
