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^99Tc^m—MIBI心肌灌注显像评价代谢综合征患者心肌血流

^99TC^m-MIBI myocardial perfusion imaging for evaluation of the myocardial blood supply in patients with metabolic syndrome
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摘要 目的应用MPI评价代谢综合征(MS)患者心肌血流灌注情况。方法选择确诊或疑似冠心病患者342例行常规门控运动+静息MPI;根据代谢指标异常情况分为4组,组1:无代谢指标异常;组2:具有1个代谢指标异常;组3:具有2个代谢指标异常;组4:具有3个或3个以上代谢指标异常。分析代谢指标异常数量与MPI的关系。对符合中华医学会糖尿病分会MS诊断标准、在显像前后1个月内行CAG检查的103例患者的MPI结果,以CAG结果为标准,分析2种方法间诊断的一致性。采用SPSS13.0软件,组间心肌灌注异常的发生率比较采用x。检验,方法间的一致性分析用Kappa检验。结果(1)与CAG比较,MPI诊断冠心病的灵敏度为80.5%(33/41),特异性85.5%(53/62),阳性预测值78.6%(33/42),阴性预测值86.9%(53/61),诊断准确性为83.5%(86/103),惭值为0.657,P〈0.001。(2)随代谢指标异常数量增加,心肌灌注异常的发生率增加:组1为23.3%(10/43),组2为32.9%(26/79),组3为54.4%(56/103),组4为57.3%(67/117),X2:23.22,P〈0.001。结论MPI可以应用于IS患者的心肌血流评估;代谢指标异常数量增加,心肌灌注异常的发生率增加。 Objective To evaluate the myocardial blood supply in patients with metabolic syndrome (MS) using ^99Tc^m-MIBI SPECT MPI. Methods A total of 342 patients were divided into four groups according to the number of abnormal metabolic indices : no abnormal metabolic index ( Group 1 ), one abnormal index ( Group 2 ), two abnormal indices ( Group 3 ), three or more abnormal indices ( Group 4). Each patient underwent two-day protocol of gated stress and rest ^99Tc^m-MIBI MPI. One hundred and three of the 342 patients were clinically diagnosed as MS and underwent CAG within 1 month after MPI. X2 test was used to evaluate the difference among the four groups and Kappa test to analyze the correlation between MPI and CAG. Results Compared with CAG, the diagnostic sensitivity, specificity, positive and negative predictive values by ^99Tc^m-MIBI SPECT MPI for coronary artery diseases (CAD) in 103 MS patients were 80.5% (33/41), 85.5% (53/62), 78.6% (33/42) and 86.9% (53/61), respectively. The correlation coefficient between MPI and CAG was 0. 657 ( P 〈 0. 001 ). The abnormal MPI rates in group 1, 2, 3 and4 were 23.3% (10/43), 32.9% (26/79), 54.4% (56/103), and 57.3% (67/ 117), respectively (X2 =23.22, P〈0.001). Conclusions In MS patients,^99Tc^m-MIBI SPECT MPI can be useful for evaluating myocardial blood supply and the myocardial ischemia rates may correlate positively with the number of abnormal metabolic indices.
出处 《中华核医学杂志》 CAS CSCD 北大核心 2011年第3期174-177,共4页 Chinese Journal of Nuclear Medicine
关键词 冠状动脉疾病 代谢综合征 体层摄影术 发射型计算机 单光子 MIBI Coronary disease Metabolic syndrome Tomography, emission-computed, single-photon MIBI
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参考文献10

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